California Institute of Technology

University of California

Paul H Patterson

Sarkis K Mazmanian

Viviana Gradinaru

Elaine Y Hsiao

Benjamin E Deverman

Sara McBride

Antoinette Bailey

Ali Khoshnan

Clifford J Woolf

Michael A Fischbach

Brittany D Needham

Gil Sharon

Masanori Funabashi

Janet Chow

Jan Ko

Ronit Lahav

Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include(e.g.,, and/or), and/or(e.g.,, or). Upon treatment, one or more ASD-related behaviors can be improved in the subject.

Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders

Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.

Selective recovery

Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus

Probiotic therapies for treating Rett syndrome

Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset, or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

Modulation of microbial synthesis of 4-ethylphenol and 4-ethylphenyl sulfate in behavior and disease

Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The subject in need thereof can have a gut microbiota signature characteristic of an adult. The bacterial species can include(e.g.,, and/or), and/or(e.g.,, or). Upon treatment, one or more ASD-related behaviors can be improved in the subject.

Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.

Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease

Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD.

Growing community of inventors

Altadena, CA, United States of America

Paul H Patterson