Incyte Genomics, Inc.

Paul H Lee

Lyle J Arnold

Samuel P Sawan

Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H N&mdash;(CH ) &mdash;SiX where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.

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Pleasanton, CA, United States of America

Paul H Lee