University of Exeter

Queen Mary & Westfield College

Paul Graham Winyard

Yuti Chernajovsky

Nigel Benjamin

Mark Elliott Wood

Alexis Perry

Matthew Whiteman

Alison Curnow

Daniel Colin Jeremy Ferguson

David Perrett

Bjarne Faurholm

Ahuva Nissim

Francesco Dell'Accio

Christopher Hughes

Stephen Mather

Michael John Kershaw

Nicholas Jose Talbot

The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and(ii) a photosensitizer or photosensitizer precursor;for use in photodynamic therapy.

Combinations of a photosensitizer with a hydrogen sulfide donor, thioredoxin inhibitor or nitroxide for use in photodynamic therapy

Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.

The present invention provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (CII) in which the antibody or fragment thereof is conjugated to a pharmaceutically active moiety. The invention also provides a composition comprising an antibody or fragment thereof against oxidized Collagen II (Gil) and a detectable label. The invention further provides the use of such compositions in medicine, in particular for the treatment of an arthropathy, and in methods of diagnosis.

Antibody and use in diagnosis and therapy of arthropathies

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Exeter, United Kingdom

Paul Graham Winyard