Synthetic Genomics, Inc.

Dsm IP Assets B.v.

Dow Agrosciences LLC

Other

Midwest Research Institute

Martek Biosciences Corporation

Algenol Biotech LLC

Merck Biosciences Corporation

Dow Global Technolgoies LLC

Paul Gordon Roessler

James George Metz

Bo Liu

Jerry Kuner

Terence Anthony Walsh

Scott Bevan

Daniel Gachotte

Ann Owens Merlo

Jessica Roxane Kristof

T Dave Matthews

Tom M Ramseier

Eric E Jarvis

Kevin T Watts

Gena Roy

Stephen K Picataggio

Dayakar Reddy Pareddy

Heike Enke

John B Ohlrogge

John Verruto

Ming-De Deng

Kevin V Martin

Lada Rasochova

Kui Wang

You Chen

Corey Neal Dodge

Christian Weissert

Terri Goodman Dunahay

Frank Jochem

Songhua Zhu

Charles Ryan Budinoff

Jerry M Kuner

Kevin Watts

Vincent D Lee

The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).

Production of DHA and other LC PUFAs in plants

The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

Recombinant photosynthetic microorganisms that convert inorganic carbon to secreted fatty acids are described. Methods to recover the secreted fatty acids from the culture medium without the need for cell harvesting are also described.

Secretion of fatty acids by photosynthetic microorganisms

The invention provides genetically modified cyanobacterial cells that are capable of utilizing phosphite as a primary phosphorus source, and can out-compete contaminant organisms for certain forms of phosphorus more effectively.

Cyanobacterial strains capable of utilizing phosphite

The present invention provides novel genes encoding Class II acyl-ACP thioesterases and variants thereof that are active on C8, C10, C12, C14, C16, and C18 acyl-ACP substrates. The thioesterases can be introduced into transgenic organisms, including microorganisms and photosynthetic organisms, for producing fatty acids and fatty acid products.

Acyl-ACP thioesterase genes and uses therefor

The present invention provides genes, polypeptides and expression constructs therefor, recombinant photosynthetic microorganisms, and method of use thereof, such as for the production of branched-chain alcohols (including 2-methyl-1-butanol, 3-methyl-1-butanol, and isobutanol) and derivatives thereof for a variety of uses.

Production of branched-chain alcohols by photosynthetic microorganisms

Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, &#x3b1;-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as a method of transformation of Thraustochytriales microorganisms. The recombinant nucleic acid molecules of the present invention can be used for the expression of foreign nucleic acids in a Thraustochytriales microorganism as well as for the deletion, mutation, or inactivation of genes in Thraustochytriales microorganisms.

Product and process for transformation of thraustochytriales microorganisms

Genes and strains of recombinant microorganisms are provided that are engineered to produce fatty alcohols and fatty alcohol derivatives. The organisms can include one, two, three or more transgenes that direct the biosynthesis of one or more fatty alcohols or derivatives. Methods of producing fatty alcohols using transgenic microorganisms are also provided.

Microbial production of fatty alcohols

This invention describes genes, metabolic pathways, microbial strains and methods to produce 2,6-dimethyloctane as an advanced biofuel from renewable feedstocks.

Dimethyloctane as an advanced biofuel

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San Diego, CA, United States of America

Paul Gordon Roessler