Isp Investments Inc.

Gaf Chemicals Corporation

Isp Chemicals Inc.

Paul Garelick

John J Merianos

Robert B Login

Susan M Lindstrom

Jenn S Shih

Krystyna Plochocka

Gary Dandreaux

Max Negrin

Russell B Biss

Herbert A Lieberman

Karen W Winkowski

Xianbin Liu

Todd Elder

Robert P Login

What is described herein are antimicrobial compositions which are defined blends of a 1,2-diol and phenoxyethanol which show broad activity against bacteria, fungi and mold spores. This activity is potentiated by the addition thereto of small amounts of a co-biocide for which the blend acts as a delivery system for the otherwise water-insoluble co-biocide.

Antimicrobial compositions

An antimicrobial composition of 3-iodo-2-propynylbutyl carbamate (IPBC) and 1,3-butylene glycol (BG) as solvent, in a defined weight ratio, preferably 9-11% IPBC and 89-91% BG, and personal care formulations including the composition in an amount of about 0.1-0.2% therein, at a pH of 4-9, is described.

Antimicrobial composition of 3-iodo-2-propynylbutyl carbamate and 1,3-butylene glycol as solvent

This invention relates to a broad spectrum antimicrobial composition, effective against gram negative and gram positive bacteria and fungi, which comprises a synergistic composition comprising iodopropynyl butyl carbamate and a bicyclic hydroxymethyl oxazolidine containing less than 0.1% of free formaldehyde.

Antimicrobial oxazolidine/iodopropynyl-butyl carbamate composition containing less than 0.1wt% free formaldehyde

A water soluble, antimicrobial composition having antifungal activity useful for disinfecting a contact lens comprise (a) polyhexamethylene biguanide and (b) iodopropynylbutyl carbamate, in a weight ratio of (a):(b) of at least 100:1.

Water soluble, antimicrobial compositions of polyhexamethylene biguanide

This invention relates to an antifungal block copolymer of poly(vinyl lactam) having the formula ##STR1## where m has a value of from 1 to 3 and from about 15 to about 25 wt. % of a quaternized amino alkyl acrylamide comonomer wherein the quaternizing anion is in part halide --O--CO(CH.sub.2).sub.s CH.dbd.CHZ wherein s has a value of from 4 to 14 and Z is hydrogen or a C.sub.1 to C.sub.4 alkyl radical, which copolymer is comprised of the following units ##STR2## wherein m has a value of from 1 to 3; p has a value of from 1 to 5; r has a value of from 2 to 6; each of X and Y is hydrogen or a C.sub.1 to C.sub.4 alkyl and each of R.sub.1, R.sub.2 and R.sub.3 is C.sub.1 to C.sub.4 alkyl. The invention also relates to the use of the above polymers as antifungal agents.

Water soluble polymers having antifungal properties

Urea-hydrogen peroxide-polyvinylpyrrolidone (PVP) in the form of a free-flowing powder is stable against decomposition in water and alcohol solvents. The product is obtained by spraying an aqueous solution of urea-hydrogen peroxide onto a fluidized bed of PVP and drying; it contains about 5%-20% by weight H.sub.2 O.sub.2 and less than about 5% water. The urea-hydrogen peroxide solution is applied onto the fluidized PVP bed at a predetermined rate, suitably about 0.5-30 g of solution/minute/kg PVP in the bed, and, preferably, about 1-3 g/min/kg PVP.

Urea-hydrogen peroxide-polyvinylpyrrolidone process

A toothpaste composition is provided which includes the strontium salt of maleic anhydride-methyl vinyl ether copolymer. This ingredient is capable of desensitizing the nerve endings of a tooth in saliva or water because of an extension of the contact time of the strontium on the tooth surface.

Toothpaste composition containing strontium salt of maleic

Urea-hydrogen peroxide-polyvinylpyrrolidone

A method of preparing a stable, low K-value, water-soluble polyvinylpyrrolidone-iodine product in the form of a uniform, free-flowing powder which comprises mixing a given amount of water-soluble polyvinylpyrrolidone polymer having a K-value of about 10-20 and about 10-20% by wt. iodine, and about 0.1-0.5% isopropanol, intimately mixing the reactants at room temperature for a sufficient period of time for the iodine to disappear as a separate phase, and then heating the reaction powders while mixing at about 65.degree.-85.degree. C. for a reaction period of at least about 18 hours.

Process for preparing a stable, low K-value, water-soluble PVP-iodine

A process for preparing a water-insoluble PVP-iodine product which comprises intimately mixing water-insoluble PVP, about 10 to 20% by weight of iodine powder and about 0.05 to 1% by weight of isopropanol, heating the reaction mixture at a mixing temperature of about 30.degree.-60.degree. C. for about 0.5 to 6 hours, and heating the mixture at a reaction temperature of about 75.degree. to 98.degree. C. for about 10-24 hours, thereupon forming a stable, uniform, free-flowing powder having an available iodine content of about 9-13% and an iodide content of about 4-6%.

Process for preparing water-insoluble PVP-iodine product

What is provided herein is a stabilized, aqueous, film-forming, antimicrobial composition of hydrogen peroxide. The active, oxygen-generating hydrogen peroxide component in the composition is stabilized in an aqueous-polyol solvent system of predetermined polarity containing PVP. In contrast, similar formulations without PVP experienced a loss of peroxide activity upon standing. Suitably, the composition herein includes about 1-20% by weight hydrogen peroxide, about 0.1-50% by weight PVP, and about 0.1-80% by weight of a polyol, the rest being water. Preferably, about 5-20% by weight of water is present in the composition. Additional solvents may be included therein, such as alcohols, ether oxides, esters, triglycerides of fatty acids, hydrocarbons, N-vinyl lactams, silicone oils, and polyether oligomers.

Stabilized, aqueous, film-forming antimicrobial compositions of hydrogen

What is provided herein is a semi-anhydrous, suspension process for preparing substantially anhydrous complexes of PVP and H.sub.2 O.sub.2 containing about 18% to about 22% by weight H.sub.2 O.sub.2. The process comprises suspending substantially anhydrous PVP and an aqueous solution of 70 to 85% H.sub.2 O.sub.2 in an anhydrous ethyl acetate medium to precipitate a free-flowing, fine white powders of the complex, and filtering and drying under vacuum at about 40.degree.-50.degree. C. to form the desired product.

Semi-anhydrous, suspension process for preparing uniform, free-flowing,

What is described herein are polymerizable pyrrolidonyl 4,5-unsubstituted oxazoline monomers, homopolymers thereof, and copolymers with other monomers. A preferred polymerizable monomer compound is 2-(1-methyl-2-pyrrolidon-4-yl)-2-oxazoline. The polymers herein have excellent hydrotropic properties thus increasing the water solubility of organic compounds previously considered as water insoluble, and exhibit complexation with water soluble cosolutes.

Poly(pyrrolidonyl oxazoline)

What is described herein are polymerizable pyrrolidonyl 4,5-unsubstituted oxazoline monomers, homopolymers thereof, and copolymers with other monomers. A preferred polymerizable monomer compound is 2-(1-methyl-2-pyrrolidon-4-yl)-2- oxazoline. The polymers herein have excellent hydrotropic properties thus increasing the water solubility of organic compounds previously considered as water insoluble, and exhibit complexation with water soluble consolutes.

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South Plainfield, NJ, United States of America

Paul Garelick