Inex Pharmaceuticals Corporation

The University of British Columbia

Paul G Tardi

Marcel B Bally

Lawrence D Mayer

Murray S Webb

James Jackson Miller

Pieter Rutter Cullis

Erik Swartz

Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.

Sphingosomes for enhanced drug delivery

Methods of increasing the circulation half-life of protein-based therapeutics in a host, the methods comprising: (a) administering to the host an amount of a first liposome formulation comprising liposomes and an antineoplastic agent; and (b) administering to the host a second formulation comprising the protein-based therapeutic, wherein the amount of the first liposome formulation is sufficient to suppress an immune response to the protein-based therapeutic of the second formulation, thereby increasing the circulation half-life of the protein-based therapeutic.

Methods for increasing the circulation half-life of protein-based

Growing community of inventors

Richmond, Canada

Paul G Tardi