Smithkline Beecham (Cork) Ltd

Sb Pharmco Puerto Rico Inc.

Vitae Pharmaceuticals, Inc.

Paul G Spoors

Christopher S Brook

Wei Chen

Philip C Dell'Orco

Lee M Katrincic

Choon K Oh

Christopher Werner

Ann Marie Louvet

David A Claremon

David H Igo

Lara Kallander

Qunying Dai

Li-Jen Ping

Ann Marie Diederich

Pingyun Y Chen

Clifford S Labaw

Claire Hisler

Jun Wang

Disclosed is a process for the preparation of a tetrahydropyran-di-amine represented by Structural Formula (I): wherein R1 is H or alkyl and E is H or an amine protecting group. 

Process for the preparation of renin inhibitors

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

Carvedilol phosphate salts and/or solvates thereof, corresponding compositions, and/or methods of treatment

The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

Carvedilol salts, corresponding compositions, methods of delivery and/or treatment

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

Carvedilol phosphate salts and/or solvates thereof, corresponding compositions and/or methods of treatment

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King of Prussia, PA, United States of America

Paul G Spoors