University of Minnesota

Other

Smithkline Beecham Corporation

Smithkline Beckman Corporation

Paul G Gassman

Ivan Lantos

Berkeley W Cue

Wilford L Mendelson

Joseph Robert Flisak

John W Mickelson

James W Hershberger

Charles H Winter

Daniel A Singleton

John R Sowa

The present invention provides a compound of the formula: ##STR1## wherein R.sup.1 is (C.sub.1 -C.sub.5)perfluoroalkyl, R.sup.2 is (C.sub.1 -C.sub.5)perfluoroalkyl or (C.sub.1 -C.sub.5)alkyl, R.sup.3 is (C.sub.1 -C.sub.5)perfluoroalkyl or (C.sub.1 -C.sub.5)alkyl, R.sup.4 is (C.sub.1 -C.sub.5)alkyl and R.sup.5 is (C.sub.1 -C.sub.5)alkyl, with the proviso that no more than two of R.sup.1, R.sup.2 and R.sup.3 can be (C.sub.1 -C.sub.5)perfluoroalkyl; and transition metal complexes thereof.

1,2,3,4-tetraalkyl-5-perfluoroalkyl-cyclopentadiene,

This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.

Intermediates for preparing epoxy esters

Process for preparation of epoxy esters and intermediates prepared

A method of conducting a Diels-Alder reaction is provided comprising reacting a Diels-Alder diene comprising a 1,3-conjugated diene with a dienophile comprising an alpha,beta-unsaturated acetal or ketal in the presence of a protonating acid to yield a [4+2] cycloadduct.

Oxygen-substituted allyl cations as dienophiles

Perfluoroalkylcyclopentadienylthallium compounds of the general formula: ##STR1## wherein n=1-5 are disclosed which are useful to modify the properties of transition metal complexes by the introduction of an electron-withdrawing perfluoroalkylcyclopentadienyl moiety thereinto.

(Perfluoroalkyl)-cyclopentadienylthallium

A method based on a cyclic single electron transfer mechanism has been developed for the electrochemical initiation and interruption of the exothermic quadricyclane to norbornadiene conversion.

Method for the electrochemical conversion of a quadricyclane to a

An aniline is converted to a 3-lower hydrocarbonthiooxindole by processes already known in the art and then air oxidized in an inert liquid vehicle in the presence of a base. The inert liquid vehicle advantageously is aprotic and the base is non-nucleophilic. Also, the aprotic liquid vehicle is desirably solvent for the starting 3-lower hydrocarbonthiooxindole and the non-nucleophilic base.

Air oxidation of oxindoles to isatins

An aniline is converted to a 3-lower hydrocarbonthiooxindole by processes already known in the art, the product converted to a 3-halo-3-lower hydrocarbonthiooxindole by oxidative halogenation, and the product subjected to hydrolysis to form the desired isatins.

Growing community of inventors

Saint Paul, MN, United States of America

Paul G Gassman