Vor Biopharma Inc.

Trishula Therapeutics, Inc.

Paul Fredrick Widboom

Anthony Boitano

John Corbin

Rahul Palchaudhuri

Vanessa Soros

Michael Cooke

Bradley R Pearse

Rajiv Panwar

Patricia Ann Cruite

Courtney Beers

Maria Kovalenko

Joseph Robert Warfield

Charlotte Fenton McDonagh

Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.

Anti-CD45 antibodies and conjugates thereof

Provided herein are antibodies that selectively bind to CD39 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Anti-CD39 antibodies

Growing community of inventors

Hanover, NH, United States of America

Paul Fredrick Widboom