Carl Zeiss Meditec Gmbh

Fitbit, Inc.

Nellcor Puritan Bennett Incorporated

Covidien LP

University of Southern California

Carl Zeiss Meditec Ag

Doheny Eye Institute

Paul Francis Stetson

Scott A Meyer

Matthew J Everett

Yan Zhou

Peter W Richards

Homayoun Bagherinia

Mary K Durbin

Javier L Prieto

Kevin Pu Weekly

Aniket Sanjay Deshpande

Kyle P Nadeau

Lindsey Michelle Sunden

Shahram Shawn Dastmalchi

Chris Hanrahan Sarantos

Srinivas R Sadda

Belen Lafon

Alexander Statan

Man-Chi Liu

Bagrat Amirbekian

Derrick Steven Vickers

Elena Perez

James Horng-Kuang Lin

James Ochs

Alexandre R Tumlinson

Jochen Straub

Julian Maclaren

Vahe Tshitoyan

Christopher Hanrahan Sarantos

Systems, devices, and methods for tracking one or more physiological metrics (e.g., heart rate, blood oxygen saturation, and the like) of a user are described. For example, one or more light sources and one or more light detectors may be positioned on a wearable device such that light can be emitted towards the user's skin and further such that light reflected back to the wearable device can be measured and used to generate values for the one or more physiological metrics.

Multiple source-detector pair photoplethysmography (PPG) sensor

Arousal events can be determined for a user associated with a wearable device, such as a user wearing a wearable computing device including one or more sensors. The one or more sensors may obtain EDA information that may determine a sympathetic nervous system response of the user, which may be responsive to an arousal event or an activation. Detection of events that increase the EDA response may provide information to the user regarding arousal events and provide recommendations to the user to address the arousal events to decrease their response.

Detection and response to arousal activations

The present invention is an OCT imaging system user interface for efficiently providing relevant image displays to the user. These displays are used during image acquisition to align patients and verify acquisition image quality. During image analysis, these displays indicate positional relationships between displayed data images, automatically display suspicious analysis, automatically display diagnostic data, simultaneously display similar data from multiple visits, improve access to archived data, and provide other improvements for efficient data presentation of relevant information.

User interface for efficiently displaying relevant OCT imaging data

Systems and methods for classifying abnormalities within optical coherence tomography images of the eye are presented. One embodiment of the present invention is the classification of pigment epithelial detachments (PEDs) based on characteristics of their internal reflectivity, size and shape. The classification can be based on selected subsets of the data located within or surrounding the abnormalities. Training data can be used to generate the classification scheme and the classification can be weighted to highlight specific classes of particular clinical interest.

Systems and methods for automated classification of abnormalities in optical coherence tomography images of the eye

Systems and methods that use interference signal from a sample tissue (e.g. retina) obtained in a self-referenced manner to obtain one or more characteristics about the sample tissue, such as thickness and intensity information, are discussed in the present disclosure. One example method of analyzing the sample tissue using an interferometry system includes illuminating the sample tissue with a beam of light using a spectrally broadband source. Scattered light signal is collected from the sample tissue at a detector. The signal results from optical interference between light scattered from multiple scatterers located at different depths in the tissue. The light signal is dominated by light scattered from a scatterer located within the bulk of the tissue. One or more characteristics of the sample tissue are determined based on the collected signal.

Self-referenced optical coherence tomography

Systems and methods for improving the assessment of disruption or abnormalities to retinal layers are presented. The disruptions are detected by analyzing at least one segmented boundary of optical coherence tomography data. Several different types of analysis can be used alone or in combination to make an assessment of the level of disruption to the particular boundary or layer defined by the boundary. The results can be presented as an end face image and quantified to report an amount of disruption. In one embodiment, a method for determining the disruption to the photoreceptor outer segment is described.

Assessment of retinal disruption

The present invention improves projection displays of volume data. Using the Minimum Intensity Projection (MinIP), fluid filled regions or other regions of hyporeflective tissue are displayed. By limiting the projection to partial volumes within the volume, differences in the scattering intensity within specific regions are isolated. In this way, hyperreflectivity of weakly scattering tissue can be assessed.

Non-linear projections of 3-D medical imaging data

Methods and devices for reducing noise effects in a system for measuring a physiological parameter, including receiving an input signal, obtaining an assessment of the signal quality of the input signal, selecting coefficients for a digital filter using the assessment of signal quality; and filtering the input signal using the digital filter, without comparing the filter's output signal with the input signal.

Selection of preset filter parameters based on signal quality

Systems and methods for efficiently displaying large volumes of medical imaging data using pre-defined dynamic displays to illustrate key anatomic features are described. In a preferred embodiment, one or more pulse files comprising en face images of sub sections of the volume are displayed sequentially to the user in a playback loop. These displays can aid in navigation of data for review and future data acquisition. Additional images generated from the data can be displayed next to or overlaid on the pulse files.

Standardized display of optical coherence tomography imaging data

The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.

Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues

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Piedmont, CA, United States of America

Paul Francis Stetson