Neuwave Medical, Inc.

Wisconsin Alumni Research Foundation

Micrablate

Paul Francis Laeseke

Daniel Warren Van Der Weide

Fred T Lee, Jr

Christopher Lee Brace

Susan Carol Hagness

John H Booske

Hans W Sollinger

Tausif Alam

Erik Aiken

Michael Speidel

Martin Wagner

Carson Hoffman

Emily Rae Foran

Joseph Whitehead

Will Robert Flanigan

Alexandra Nicol Doersch

Brett Conor Struthers

Joseph Alexander Ashley

Michael Woods

Fred T Lee Jr

A 'localizable' systemic gene therapy system is provided substantially increasing the transfection efficiency of the gene vectors into targeted tissue cells and substantially reducing the escape of the gene vectors from the targeted tissue volume, such as would waste the vectors, promote undesired immune reactions, and/or incur prohibitive costs for the required dose of gene-containing virus vectors. In this regard, the invention provides a means to simultaneously achieve local electroporation and gene-containing vector injection in a portion of a vascularized organ. It includes two double-balloon catheters that create contained volumes in parallel blood vessels for the introduction of vectors with reduced loss along with electrodes providing electroporation of the cells in the same location where the vectors are injected.

In vivo gene therapy delivery procedure and device

The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy with a linear array of antenna components having optimized energy delivery characteristics. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.

Energy delivery systems and uses thereof

A system and method are provided for creating both angiographic images of a subject and dynamic images of the subject from imaging data acquired during an imaging acquisition. The method includes operating an imaging system to perform an imaging acquisition by delivering interspersed doses of high doses of the ionizing radiation and low doses of the ionizing radiation, wherein more low doses of the ionizing radiation are delivered than high doses of ionizing radiation during the imaging acquisition to thereby acquire the imaging data with a high frame rate of low dose data and a low frame rate of high dose data. The method also includes generating at least volumetric angiographic images of the subject and dynamic images of the subject from the imaging data.

System and method for simultaneous acquisition of contrast dynamics and anatomical images

The present invention relates to systems and devices for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In particular, the present invention relates to systems and devices for the delivery of energy with heat transfer ability. In some embodiments, the systems and devices also have variable characteristic impedance as a result of the use of heat transfer materials. In certain embodiments, methods are provided for treating a tissue region (e.g., a tumor) through application of energy with the systems and devices of the present invention.

Transmission line with heat transfer ability

A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume.

System and method for flow-resolved, three-dimensional imaging

In vivo therapeutic delivery procedure and device

The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy.

A radiography machine provides information about the absolute dimension of imaged objects with as few as two images taken along a common axis at different separations. The information gathered in this way may also be used to deduce absolute or relative separation of the objects along the common axis.

Size measurement using angle-constrained radiographic imaging

Aspects of the disclosure are directed to methods and/or apparatuses involving the deployment and coupling of catheters. As may be implemented in accordance with one or more embodiments, each of first and second catheters extend from a proximal end to a distal end and has a magnet. The catheters may be deployed, and the distal ends of the respective catheters can be aligned and connected via magnetic coupling of the magnets to one another. A shaft structure is configured and arranged to extend within the first catheter and into the second catheter, through the connected distal ends of the respective catheters.

Catheter apparatus and method

A system and method is provided for creating motion-adjusted or motion-compensated images of a patient to guide an interventional medical procedure. The method includes displaying a static roadmap and a plurality of dynamic images to show the interventional medical device aligned on the static roadmap using a motion transformation. Alignment of the interventional medical device on the static roadmap is based on a user selection of one of motion compensation of the interventional medical device relative to the static roadmap to produce a plurality of images that do not show patient motion or motion adjustment of the static roadmap relative to the interventional medical device to produce a plurality of images that show patient motion.

Growing community of inventors

Madison, WI, United States of America

Paul Francis Laeseke