Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Paul Federer

Thomas Schlaubitz

Sven Ebert

Guido Grueter

Christian George

Stefan Vollenweider

Michal Karol Dobrzynski

Lukas Schneider

Andreas Scholle

Torsten Burdack

Guenter Tenzler

Arnulf Staib

Claudio Cherubini

Pius Hermann

Thomas Kern

Daniel Bommer

Urs Wittenwiler

Stefan Job

Michael Dobrzynski

The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.

Flow rate sensor system, method for and use of such system for determining a flow rate

The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in a microtiter plate format.

Thermocycling of a block comprising multiple sample

A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.

Method to monitor and control the temperature of a sample holder of a laboratory instrument

A sensor () for detecting a state of a fluid within a microfluidic plate () is disclosed. The sensor () comprises at least a first planar electrode () and a second planar electrode () arranged parallel to one another so as to form an electric capacitor (). The first planar electrode () and the second planar electrode () are configured to generate an electric field () within the fluid, wherein the sensor () is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (). Further, a system () for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate () is disclosed.

Sensor for detecting a state of a fluid within a microfluidic plate, system for controlling a preparation of a sample including a fluid and method for detecting a state of a fluid within a microfluidic plate

An assembly comprising a sample block, a heat sink and at least one electrodeposited thermoelectric element is disclosed. Further, an instrument and a method for performing a temperature-dependent reaction are disclosed.

Assembly, instrument for performing a temperature-dependent reaction and method for performing a temperature-dependent reaction in an assembly

The present invention discloses a thermal block unit for thermal treatment of samples comprising temperature regulating units, temperature sensors for measuring temperature at different locations of the thermal block unit, a converter for converting signals from the temperature sensors into digital signals and a thermal block interface for communicating with an instrument.

Thermal block unit

Disclosed herein are methods for monitoring a thermoelectric heating and cooling device () of a system () for cycling liquid reaction mixtures through a series of temperature excursions, and such systems adapted to perform these methods. A first quantity being either an electric current or an electric voltage is applied to the heating and cooling device () or a portion () thereof (), and a second quantity being either the non-selected first quantity or temperature is measured to obtain a first test value. The selected first quantity is applied to another thermoelectric heating and cooling device () or another portion () of the first device (), and the second quantity is measured to obtain a second test value. Comparison of the first and second test values yields a monitoring value which is compared with a pre-defined threshold value to obtain a monitoring result.

System and methods for monitoring a thermoelectric heating and cooling device

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Wolhusen, Switzerland

Paul Federer