USA As Represented by Secretary of the Navy

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Paul Falkenstein

Brian L Justus

Alan L Huston

Robert E Miller

Rosemary Altemus

Holly Ning

C Norman Coleman

Alan Lee Huston

Robert Miller

This invention pertains to a holey fiber and to a fabrication method for making the fiber. The holey fiber can transmit light by total internal reflection or by Bragg diffraction, can be single mode or multimode and can have solid core or a hollow core. The holey fiber has outside diameter typically of 20 microns to 5 mm, a hollow core of a diameter typically of 0.2 micron to 150 microns and longitudinal channels therethrough of a diameter typically of 0.1 micron to 150 microns. The channels are disposed in a desired arrangement with center-to-center distance variation of less than about 2% along the length of the fiber and the cross-section thereof is round that varies less than about 2%.

Fused array preform fabrication of holey optical fibers

A method and an apparatus for dose-guided radiotherapy for a patient (P) having an identified radiotherapy target utilizes a radiation detecting array (R) of radiation-sensitive dosimeters for the real-time remote measurement of radiotherapy at the radiation detecting array (R). The radiation detecting array is positioned within the patient's (P) body along the treatment path before or after the identified radiotherapy target or the device may be positioned beyond the patient (P) to measure transit dose. A radiation source (A) for emitting radiation for radiotherapy along a treatment path through the patient (P) to the identified radiotherapy target is utilized. The method includes generating a predicted dose pattern of radiation at the placed radiation detecting array (R). The predicted dose pattern assumes an on-target radiation source (A) emitting the radiotherapy beam along the treatment path through the patient (P) to the identified radiotherapy target. Gating of the radiation source (A) can occur responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R). Radiation intensity can vary between low levels to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R).

Apparatus and process for dose-guided radiotherapy

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Alexandria, VA, United States of America

Paul Falkenstein