Baxter International Inc.

Cardiac Pacemakers, Inc.

Mallinckrodt, Inc.

Paul F Emerson

Prakash R Keshaviah

David A Luhring

Pramodsingh Hirasingh Thakur

Donald Lee Hopper

Michael A Querimit

Chi J Chen

Daniel O'Brien

James P Ebben

Jeffrey E Stahmann

Robert W Childers

Keith R Maile

David J Ternes

John D Hatlestad

Yi Zhang

Jesse W Hartley

Kent Lee

Stephen B Ruble

Gary Thomas Seim

Gary L Hansen

Jonathan T Kwok

Patrick R Balteau

Howard D Simms, Jr

Francesco Peluso

Dirk Faict

Vital Eerlingen

James Leo Campbell

Alain Delache

Zhe Shen

Jian Ruan

Kazuo Kumano

Jim Ebben

Bradley J Bonnette

Lisa Colleran

Brian Ralph Larson

Jacques Souquet

Stephen R Pitzl

Weiguang Shao

Yan Zou

Jr Howard D Simms

A system includes an implantable medical device configured to sense a sync signal and sense physiological parameters to obtain a physiological signal. In response to sensing the sync signal, the implantable medical device is configured to generate a sync-stamped physiological signal. In certain embodiments, a method includes receiving a first physiological signal coupled with a sync signal; receiving a second physiological signal coupled with the sync signal; and, using the sync signal, synchronizing in time the first and second physiological signals.

Syncing multiple sources of physiological data

A patient-specific model can show changes in cardiac stroke volume or cardiac output, such as to predict heart failure or to indicate cardiac remodeling. The patient-specific model can be derived from a surrogate indication of a cardiac stroke volume, such as a physical activity level, and features obtained from a thoracic impedance waveform, such as mean or peak-to-peak impedance values. In an example, several models corresponding to different patient physical activity levels can be determined.

SV/CO trending via intracardiac impedance

A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.

Minute ventilation-based disordered breathing detection

A cardiac rhythm management (CRM) device can extract ventilation information from thoracic impedance or other information, and adjust a delivery rate of the CRM therapy. A tidal volume of a patient is measured and used to adjust a ventilation rate response factor. The measured tidal volume can optionally be adjusted using a ventilation rate dependent adjustment factor. The ventilation rate response factor can also be adjusted using a maximum voluntary ventilation (MVV), an age predicted maximum heart rate, a resting heart rate, and a resting ventilation determined for the patient. In various examples, a global ventilation sensor rate response factor (for a population) can be programmed into the CRM device, and automatically tailored to be appropriate for a particular patient.

Ventilation sensor rate response normalization and calculation

A rate-adaptive pacemaker and a method for its operation in which the response factor for a minute ventilation sensor or other type of exertion level sensor is automatically set during a parameter adjustment mode that utilizes an activity level measurement to determine when the patient is at a target activity level with which is associated an appropriate target pacing rate. In a preferred embodiment, the target activity level corresponds to casual walking (e.g., 2 mph at a 4% grade) with a target pacing rate selected as appropriate for that level of activity in the individual patient.

Automatic programming of rate-adaptive therapy via activity monitoring

An apparatus and method for treating sleep apnea includes a bilevel flow generator having an alternating current (AC) synchronous motor coupled to a low inertia centrifugal rotor/impeller. The process of acceleration and deceleration of the rotor involves moving from frequency A, amplitude A to frequency B, amplitude B in an optimal linear fashion using the so-called Bresenham algorithm. This is coupled with a tuned increase of the amplitude during the acceleration process which will produce the acceleration using minimum current allowing the use of smaller power supplies. During deceleration the process is accomplished in reverse fashion using a tuned decrease of the amplitude coupled with a special shunt circuit to prevent power supply voltage changes. These changes in amplitude overlay a current feedback mechanism used to prevent loss of synchronization of the motor by changing amplitude. Speed changes can also be timed so as to prevent desynchronization.

Apparatus and method for providing a breathing gas employing a bi-level flow generator with an AC synchronous motor

An apparatus for delivering a breathing gas to a patient includes a display, a storage device programmed to hold different purge hole leak profiles for a variety of mask types, and a selection mechanism for selecting one of the profiles so that accurate values of tidal volume, excess leak and peak flow may be calculated and shown on the display. The displayed excess leak value can be used to correct the fit of the mask.

Bi-level flow generator with manual standard leak adjustment

An improved peritoneal dialysis method and system is provided. The method utilizes a tidal oscillating pulse peritoneal dialysis system. To this end, a system for providing peritoneal dialysis to a patient is provided. The system comprises a single catheter that is placed in the patient, a reservoir of dialysate having a volume greater than or equal to three liters, and a single pump for pumping the dialysate from the reservoir into and out of the patient.

Method and apparatus for a tidal oscillating pulse peritoneal dialysis

A system and a method are provided for admixing solutions. The system includes containers separately accessible by one or more pumps for mixture of the solutions in a container immediately before administration to a peritoneal cavity of a patient. Alternatively, the system and method allow for direct administration of the mixed solution to the peritoneal cavity of a patient without intermediate mixing thereof. The solutions may be mixed in predetermined ratios as input to the system prior to delivery.

System and method for providing sterile fluids for admixed solutions in

An improved on-line, real time hemodialysis monitoring system for hemodialysis treatment, quantitates the rate and amount of a constituent, such as urea, removed during the hemodialysis treating by measuring the constituent concentrations as a function of time in the spent dialysate effluent from a hemodialysis machine. A quantity of the spent dialysate effluent is removed from the dialysate effluent waste line periodically for testing. A urea concentration time profile can be analyzed to determine the urea removal, KT/V, URR, SRI, and normalized protein catabolic rate (nPCR) indices. The hemodialysis monitoring system preferably can obtain a dialysate sample equilibrated with the blood prior to the start of a hemodialysis treatment. In a further aspect of the hemodialysis monitoring system includes a device for conducting two-pool analysis for taking into account the constituent concentration differences in the extracellular and intracellular spaces in the hemodialysis patient during the hemodialysis treatment to determine the intercompartmental transfer coefficient K.sub.I of a patient, which allows more precise adjustment of the hemodialysis prescription for the patient.

Automatic apparatus for obtaining equilibration samples of dialysate

There is disclosed a method and apparatus for automatically conducting peritoneal equilibration testing. The method involves removing a sample of overnight dwell fluid from a patient in an amount sufficient to determine the concentration of a metabolite in the drain fluid. The concentration of the metabolite in the sample is then detected and the overnight dwell fluid is drained and weighed. A known weight of dialysate fluid is instilled into a patient and thereafter there are periodically withdrawn samples of the dialysate fluid and the concentration of metabolite in each sample is determined. The ratio of metabolite concentration of each of the periodically drawn samples to metabolite concentration for the overnight dwell fluid is determined. The patient is then drained after a predetermined dwell time and the volume of drained dialysate is determined. The mass transfer area coefficient of the patient's peritoneal membrane is then obtained as a function of the measured variables. Means are provided for conducting the method for each of the steps described.

Apparatus and method for automatically performing peritoneal

An improved on-line real time hemodialysis monitoring system for hemodialysis treatment. The hemodialysis monitoring system quantitates the rate and amount of a constituent, such as urea, removed during the hemodialysis treatment by measuring the constituent concentrations as a function of time in the spent dialysate effluent from a hemodialysis machine. A quantity of the spent dialysate effluent is removed from the dialysate effluent waste line periodically for testing. A urea concentration time profile can be analyzed to determined the urea removal, KT/V, URR, SRI and normalized protein catabolic rate (nPCR) indices. The hemodialysis monitoring system preferably can obtain a dialysate sample equilibrated with the blood prior to the start of a hemodialysis treatment. The hemodialysis monitoring system includes a two pool analysis for taking into account the constituent concentration differences in the extracellular and intracellular spaces in the hemodialysis patient during the hemodialysis treatment.

Hemodialysis monitoring system for hemodialysis machines

The present invention provides an improved peritoneal dialysis method and system. The system comprises a single catheter that is placed in the patient, a source of dialysate, and a diatyzer in fluid communication with the source of dialysate and the catheter. The system includes a single fluid pump in fluid communication with the source of dialysate and the catheter. The single pump is capable of pumping the dialysate into and out of the patient and back to the source of dialysate. The method includes the steps of placing a single catheter in a peritoneum of the patient, providing a source of dialysate, coupling the source of dialysate in fluid communication with the catheter on a single fluid circuit, pumping the dialysate from the source of dialysate into and out of the peritoneum using a single pump in the single fluid circuit.

Method and apparatus for purified pulse peritoneal dialysis using a

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St. Louis Park, MN, United States of America

Paul F Emerson