Hewlett-packard Company

Paul F Bente, Iii

Joel Myerson

Ernest H Zerenner

Raymond D Dandeneau

In forming an electrophoretic gel, various defects can be induced by the shrinkage that generally accompanies polymerization. These defects can include pulling away from a vessel wall or voids or bubbles forming within the gel itself. Prior to polymerization, a monomer can be compressed to a density at least equal to that of the expected density of the final gel, which then is substantially free of such shrinkage defects. The disclosed method is readily generalizable to other situations to produce polymers substantially free of defects due to shrinkage.

Method of preventing shrinkage defects in electrophoretic gel columns

An open tubular or capillary chromatographic column made from drawn silica tubing having an exterior coating for protection from abrasion and moisture and means for holding it in a desired configuration.

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Landenberg, PA, United States of America

Paul F Bente, Iii