Charterhouse Therapeutics Ltd.

Crawford Healthcare Holdings Limited

Paul Evans

Stanley Michael Roberts

Maria Gabriella Santoro

Alan Michael Happe

Vasudev Jadhav

Nicolette Christa Ross

Timothy James Snape

Mazhar Iqbal

A compound comprising a cyclopentanone, cyclopentenone, cyclohexanone or cyclohexenone group, wherein a first ring carbon atom carries an &#x2014;SR substituent, R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group that, optionally, includes at least one heteroatom in its carbon skeleton, the remaining available ring carbon atoms are optionally substituted, and said compound either: &#x2014;(a) is more soluble in water at a temperature of 20-40&#xb0; C.; (b) is less lipophilic; and/or, (c) has a greater therapeutic index; or; (d) is less soluble in water at a temperature of 20-40&#xb0; C.; (e) is more lipophilic; and/or, (f) has a greater therapeutic index; than an equivalent cyclohex-2-en-1-one or cyclopent-2-en-1-one derivative in which a hydrogen atom replaces said &#x2014;SR group. 

Pharmaceutical compositions

A method of preparing prostanoid cross-conjugated dienones, via a tandem conjugate addition-Peterson olefination reaction route is described. Such compounds may be useful in medicine and other fields.

Synthetic method and novel chemical compounds

Growing community of inventors

Liverpool, United Kingdom

Paul Evans