Corning Incorporated

Paul Ernest Gagnon, Jr

Gregory Roger Martin

Allison Jean Tanner

Paul Michael Szlosek

Scott Matthew Bennett

Brian Robb Douglass

Hongming Wang

Dana Craig Bookbinder

John Stephen Peanasky

Ye Fang

Joydeep Lahiri

Shawn Michael O'Malley

Arthur Winston Martin

Marie D Bryhan

Oliva V LaChance

Zhong-he Shen

Terry T Goodrich

Jodelle Karen Nelson

Jun Xi

A spheroid cell culture article including:

Spheroid cell culture article and methods thereof

Spheroid cell culture well article and methods thereof

Disclosed herein are functionalized cationic peptide monomers: peptide chains of two or more positively charged amino acids chosen from lysine or arginine, or derivatives thereof, which are functionalized, meaning that they are bound to one or more polymerization moieties. The functionalized cationic peptide monomers can be described by the formula Z-Xaa-Zwherein Z and Zare polymerization moieties and n1 is an integer of 0 or 1; Xaa is each independently an amino acid Lys or Arg and n is an integer from 2 to 10 and wherein at least one Xaa amino acid of Xaa is Lys, wherein the carboxyl terminus of the amino acid sequence is amidated. Functionalized cationic peptide monomers can be combined and polymerized to form cell culture surfaces.

Polymerizable catonic peptide monomers and polymers

A method of producing an improved cell growth surface and cell attachment surface. According to the present invention, a polymer article is molded at temperature in excess of 550&#xb0; F. at the injection tip. After allowing the part to cool, a stream of plasma comprised of activated gaseous species generated by a microwave source is imparted on the article. This stream is directed at the surface of a polymer substrate in a controlled fashion such that the surface is imparted with attributes for cell adhesion superior to those of untreated polymer or polymer treated by other methods.

Method of making enhanced cell growth surface

Disclosed is a cell culture article including: a substrate; a tie-layer attached to at least the substrate; and a bio-compatible layer attached to at least the tie layer, the bio-compatible layer having been obtained from surface oxidation of a polymer layer. Also disclosed are methods for making the cell culture article and methods for performing an assay of a ligand with the article.

Cell culture article and methods thereof

Growing community of inventors

Wells, ME, United States of America

Paul Ernest Gagnon, Jr