University of Pittsburgh

Paul Edward Floreancig

Billy W Day

Alexander Deiters

Fanghui Wu

Ramsey D Hanna

Shuangyi Wan

Yuta R Naro

A compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein L is a cleavable linker group;X is a cargo moiety-containing group; andRand Rare each independently hydrogen, alkyl, or substituted alkyl; or Rand Rtogether form a boronic ester ring or a substituted boronic ester group.

Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles

Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold includes a substituent at the C8 and/or C11 positions that may include a linker that may be conjugated to a targeting moiety. The pederin/psymberin chimera scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The pederin, psymberin or pederin/psymberin chimera scaffold may be modified to include substituents at positions other than the C10 or C13 of pederin, or the C8 and C11 of psymberin.

Pederin and psymberin agents

Growing community of inventors

Pittsburgh, PA, United States of America

Paul Edward Floreancig