Schering Aktiengesellschaft

Paul-Eberhard Schulze

Bernard Acksteiner

Ulrich Kerb

Henry Laurent

Ulrich Speck

Gerhard Sauer

Klaus Nickisch

Helmut Wachtel

Herbert H Schneider

Werner Krause

Wolfgang Mutzel

Reinhard Horowski

Heinrich Pfeiffer

Bob Nieuweboer

Bernd Dusterberg

Peter-Andreas Loschmann

Rainer Dorow

Kunhard Pollow

Michael Humpel

Hans-Martin Siefert

Bernhard Acksteiner

Bernd Dusterlerg

The invention relates to a process for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material, characterized by either binding the compound to be determined and its deuterated analog to an antibody present in excess, which antibody is coupled to a stationary phase of a polymeric material, and separating the two compounds from the antibody and measuring by mass spectrometry the proportion of deuterated compound/not deuterated compound or, respectively, cross-reacting compound; or, in case a suitable deuterated or cross-reacting compound is not available, utilizing as the internal standard also a chemically similar compound which, however, is added after the antibody-mediated extraction, and inserting a separating process before mass spectrometry.

Method for the determination of small substance quantities of medicines,

Novel, multiple-tritiated steroid-20,17-spirolactones of general Formula I ##STR1## wherein --A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or ##STR2## and --C--D-- is ##STR3## R is hydrogen or tritium and n is 0 or 1, are usable as tracer materials for the detection of mineralocorticoid receptors.

Multiply-tritiated steroidal-20,17-spirolactones and their use as tracer

Compounds of general Formula I labeled with .sup.121 I, .sup.122 I, .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I and .sup.132 I isotopes ##STR1## wherein R.sup.6 is a C.sub.1-6 aliphatic hydrocarbon residue and

I*-diagnostics for monoamine receptors using ergolines

An aqueous crystalline suspension of a 17-tertiary steroid glycoester contains a compound of Formula I ##STR1## wherein X is two hydrogen atoms or an oxygen atom,

Aqueous crystalline suspension of steroid glycoesters

Glycoesters of estradiol (E.sub.2) and of estriol (E.sub.3) of Formula I

Glycoesters of estradiol and estriol

Compounds of the formula ##STR1## wherein R.sup.1 is hydroxy-C.sub.2-8 -alkyl containing 1-5 OH-groups;

Triiodinated 5-aminoisophthalic acid derivatives

A process for preparing an 11-keto steroid consists essentially of heating the corresponding 9.alpha.-halo-11.beta.-hydroxy steroid, to 180.degree.-350.degree. C. in an inert, aprotic, high-boiling solvent.

Process for preparing 11-keto steroids

A process for preparing a .DELTA..sup.9(11) - and/or .DELTA..sup.16 -unsaturated steroid comprises heating the corresponding steroid of the pregnane series substituted by 9.alpha.-chloro- and/or 16.alpha.-chloro- or 17.alpha.-acyloxy, in an inert, aprotic high-boiling solvent at 180.degree.-350.degree. C.

Process for preparing .DELTA..sup.9(11) and/or .DELTA..sup.16

Organic radiohalogen compounds are prepared by heating in a non-aqueous liquid phase a mixture of a radioinactive organic halogen compound and an alkali metal halogenide or alkaline earth halogenide wherein the halogenide is F-18, Cl-38, Br-82 or I-123, -125, -131 or -132.

Growing community of inventors

Berlin, Germany

Paul-Eberhard Schulze