Human Genome Sciences, Inc.

Georgetown University

Avalon Pharmaceuticals, Inc.

Other

Paul E Young

Steven M Ruben

Craig A Rosen

Henrik S Olsen

Jian Ni

Daniel R Soppet

Reinhard Ebner

Paul A Moore

Yanggu Shi

Kimberly A Florence

Laurie A Brewer

Gregory A Endress

Ying-Fei Wei

John M Greene

Kenneth C Carter

Ann MeeJin Ferrie

David W LaFleur

Roxanne Duan

George Komatsoulis

Guo-Liang Yu

Carrie L Fischer

Jing-Shan Hu

Ping Feng

Michael Mucenski

Kevin P Baker

Yi Li

David William Lafleur

Charles E Birse

Hla Kyaw

Zhizhen Zeng

C Richter King

Daniel P Bednarik

Ping Wei

Mia Hijazi

Michele Fiscella

Reiner L Gentz

Patrick J Dillon

Haodong Li

Gregg A Hastings

Stanislaw Pikul

David K Bol

Ping Fan

Joseph J Kenny

Charles Florence

Paul Richard Crocker

Jeffrey W Strovel

Richter C King

Ding Liu

Fouad Janat

Mai Hijazi

Daniel P Soppet

Daniel R Bednarik

The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

12 human secreted proteins

Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.

Chemo-centric selection of disease-related genetic profiles

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

Antibodies to HBIMF63 polypeptide

The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS.A-B, FIGS.A-C, and FIG.respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

Peptidoglycan recognition proteins

The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.

Heregulin-like factor

The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

Polynucleotides encoding dendritic enriched secreted lymphocyte activation molecule

Antibodies to HHPEN62 polypeptide

The present invention relates to novel human apoptosis related polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human apoptosis related polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human apoptosis related polypeptides.

Apoptosis related polynucleotides, polypeptides, and antibodies

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

Secreted protein HRGDF73

Heregulin-like factor antibodies

The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS.A&#x2013;B, FIGS.A&#x2013;C, and FIG., respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

Dendritic enriched secreted lymphocyte activation molecule

The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.

Human tumor necrosis factor receptors TR13 and TR14

Secreted protein HCE3C63

Antibodies to protein HPMBQ91

Growing community of inventors

Gaithersburg, MD, United States of America

Paul E Young