Procyon Pharmaceuticals, Inc.

Alder Research Center Limited Partnership

Paul E Driedger

James Quick

Compositions of matter having protein kinase C-modulatory, anti-inflammatory and other biological activities are disclosed. The compositions are derived from indolactams which have a substituent, containing at least one carbon, at the N position and have ether substitution on the 14-O position.

Protein kinase C modulators. W.

Compositions with protein kinase C-modulatory, anti-inflammatory and other activities are disclosed.

Protein kinase C modulators N

Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the polyacetate-, diaminobenzyl alcohol-, diacylglycerol- and bryostatin-classes.

Protein kinase C modulators V

Compounds having anti-inflammatory, anti-viral, protein kinase C-modulatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class, each bearing an additional 6-atom chain connecting positions 3 and 4 to form a fused 9-membered ring. This invention is exemplified by 9-deshydroxymethyl-9-carboxyindolactam V.

Protein kinase C modulators. C. indolactam structural-types with

Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.

Protein kinase C modulators O

Compositions having anti-inflammatory, antiviral and other activities are disclosed. The compositions are derived from phorboids of the polyacetate- and bryostatin-classes.

Polyacetate-derived phorboids having anti-inflammatory and other uses

Compositions with anti-inflammatory and other activitites are disclosed. The compositions are derived from phorboids of the diterpene- and benzolactam-classes.

Protein kinase C modulators Q

Compositions of matter and pharmaceutical compositions having protein kinase C-modulatory, anti-inflammatory, anti-viral and other activities are disclosed. The compounds are derived from tricyclic aromatic heterocyclic compounds incorporating indole, indene, benzofuran and benzothiophene structural elements.

Protein kinase C modulators. E.

Compositions of matter having protein kinase C-modulatory, anti-inflammatory, anti-viral and other activities are disclosed. The compounds are derived from tricyclic aromatic heterocyclic compounds incorporating indole, indene, benzofuran or benzothiophene structural elements.

Protein kinase C modulators. F.

Pharmaceutical compositions having antiviral, antiinflammatory and other activities are disclosed. The compositions are of compounds derived from diterpene phorboids.

Protein kinase C Modulators. L.

Compositions having anti-inflammatory, antiviral and other activities are disclosed. The compositions are derived from phorboids of the diaminobenzyl alcohol- and diacylglycerol-classes.

Protein kinase C modulators. H.

Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.

Protein kinase C modulators. K.

Compositions having protein kinase C-modulatory, anti-inflammatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class.

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Boston, MA, United States of America

Paul E Driedger