University of Pennsylvania

Gentis, Inc.

Other

S.a. Fbfc International

Boehringer Mannheim Gmbh

Orthovita, Inc.

Fbfc International S.a.

Vita Licensing, Inc.

Paul Ducheyne

Raymond Kempeneer

Marcel Louis De Clercq

Maria Martha Van Hoeylandt

Evert Schepers

Shulamith Radin

Erick Manuel Santos

Irving Shapiro

Michele S Marcolongo

Ahmed El-Ghannam

David D Devore

Frank K Ko

John M Cuckler

Charles Cohen

William LaCourse

Edward Vresilovic

Jean Chin Chin Gan

Shulamit Radin

Raymond Kempenners

Louis Van Hove

Sylvie Falaize

Portonovo S Ayyaswamy

Debra Wolfarth

Andres Jose Garcia

L D Topoleski

Sanjib Bhattacharyya

David H Kohn

Marcel DeClercq, Deceased

David Boettiger

Marcel De Clercq, Deceased

Qing-Qing Qiu

Raymond Kempeneers

D Scott Metsger

Jean Chin Gan

Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.

Coated mesoporous nanoparticles

Xerogel films on substrates are provided containing pharmaceutically active compounds. Articles incorporating such films are robust, release active compounds at predictable rates and may provide such release for relatively long periods of time. Orthopedic and trauma uses are indicated along with generalized use in contact with body fluids or as biological implants. Methods for fabrication of such films and devices are provided.

Xerogel films for the controlled release of pharmaceutically active molecules

Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.

Polymerizable emulsions for tissue engineering

Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca-P surface layer having serum-protein like organic molecules, as defined herein intermingled throughout, is described.

Conditioning of bioactive glass surfaces in protein containing solutions

Methods and materials are provided for reforming degenerated intervertebral discs of the spine of a vertebrate and in particular the spine of a human. Tissue is evacuated from the nucleus pulposus portion of a degenerated intervertebral disc space, and a biodegradable substrate containing isolated intervertebral disc cells is implanted in the evacuated space for reformation of intervertebral disc tissue. Intervertebral disc cells are provided by digesting intervertebral disc tissue with collagenase and incubating the cells in a medium supplemented with hyaluronidase. The substrate may be bioactive so as to enhance cell function. Substrates include bioactive glass granules, polymer foams and the polymer foams coated with a bioactive gel material produced by a sol-gel process. A polymer foam is dipped into a sol resulting from combining a metal alkoxide precursor with water and acid, residual sol is evacuated from pores of the foam, and remaining sol contained by the foam is allowed to gel. The polymer of the foam may be poly(D,L-lactide-co-glycolide). A preferred bioactive gel material contains 70% SiO , 25% CaO and 5% P O .

Preparation of polymer foam having gelled sol coating for intervertebral disc reformation

Hollow particles having a shell substantially composed of calcium-phosphate, methods for preparing the same, and methods of use are disclosed. The particles are obtained by differential immersion of silica-based, calcium and phosphate containing glass particles.

Hollow bone mineral-like calcium phosphate particles

Non-crystalline, porous bioactive glass and ceramic materials are prepared that permit in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells. The bioactive glass and ceramic materials are treated such that when used in contact with anchorage-dependent cells, there is enhanced cell attachment and cell function to provide expeditious tissue growth in vitro or in vivo. Treatment involves immersing the glass or ceramic material in an aqueous solution containing ions in a concentration typical of interstitial fluid followed by immersion in an aqueous solution containing at least one cell adhesion molecule. Immersion may also be in an additional aqueous solution containing an additional cell adhesion molecule before or after immersing in the solution containing ions. The glass material is preferably formed from SiO , CaO, Na O and P O . The glass material is preferably prepared by melting constituents, cooling and pulverizing the resultant glass to obtain a powder, and then forming and hot pressing the powder. The glass may be formed to produce templates, a swell as to produce granules that may be formed into a paste. An implant may be formed by coating an implant material with the treated bioactive glass or ceramic material.

Bioactive glass or ceramic substrates having bound cell adhesion molecules

Bioactive, degradable composite material and composite material microspheres were produced using a new solid-in-oil-in-water method. Compositions and methods for tissue engineering and drug delivery are provided.

Bioactive, degradable composite for tissue engineering

Methods of reforming degenerated intervertebral discs. Hybrid materials useful in methods of reforming degenerated intervertebral discs.

Compositions and methods for intervertebral disc reformation

Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca&mdash;P surface layer having serum-protein like organic molecules, as defined herein intermingled throughout, is described.

Composite materials formed from bone bioactive glass or ceramic fibers and structural fibers are disclosed. In preferred embodiments, a braid or mesh of interwoven bone bioactive glass or ceramic fibers and structural fibers is impregnated with a polymeric material to provide a composite of suitable biocompatibility and structural integrity. Most preferably, the mesh or braid is designed so that the bioactive fibers are concentrated at the surface of the implant to create a surface comprised of at least 30% bioactive material, thereby providing enhanced bone ingrowth. The interweaving between the bone bioactive glass or ceramic fibers and the core of structural fibers overcomes the problems found in prior composite systems where the bioactive material delaminates from the polymer. Preferred bioactive materials include calcium phosphate ceramics and preferred structural fibers include carbon fibers. Further preferred bioactive materials include aluminum oxide at greater than 0.2%, by mole. Improved prosthetic implants and methods of affixing an implant are thus also disclosed.

Composite materials using bone bioactive glass and ceramic fibers

Methods of reforming degenerated intervertebral discs are provided in accordance with methods of the invention. Hybrid materials useful in methods of the present invention are also provided.

Carriers comprising silica-based glass providing for the controlled release of biologically active molecules, their methods of preparation, and methods of use are disclosed. The carriers are prepared using a sol-gel-derived process. Biologically active molecules are incorporated within the matrix of the glass during production.

Incorporation of biological molecules into bioactive glasses

Growing community of inventors

Rosemont, PA, United States of America

Paul Ducheyne