Other

Enzo Biochem, Inc.

Consumer Satellite Radio, LLC

Paul Diamond

Elazar S Rabbani

James J Donegan

Eugene J Oliva

David A Dorward

The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.

Sphingosine pathway modulating compounds for the treatment of cancers

The invention provides therapeutic compositions and methods for the inhibition of metastasis and for treatment of cancers in human and non-human mammals that are directed to the coformulation and/or coadministration of a dehydropyrimidine dehydrogenase inhibitor such as gimeracil and a pyrrolopyrimidine compound.

Combination therapy for the inhibition of metastasis and tumorigenesis

Handheld cognitive and behavioral therapy implement

According to the invention, a subscriber to a first satellite radio service can be provided with an option to receive, over their current receiver unit, supplemental content, such as a particular show or channel, which is otherwise only available within a relevant jurisdiction as part of a subscription package to subscribers of one or more other satellite radio services. Thus, without purchasing a full subscription to another service, the subscriber of the first satellite radio service may arrange to receive supplemental content that is otherwise only available as part of a subscription package, such as a basic or general subscription package, to subscription holders of one or more other services. The invention also provides methods of broadcasting and methods of configuring dedicated and interoperable satellite radio receiver units so that the supplemental content can be received by a subscriber.

For fee distribution of consumer selected content items between different satellite radio service providers

For-fee distribution of consumer-selected content items between different satellite radio service providers

The invention provides methods and systems for ordering and effectuating subscriptions to a gravesite location information service in connection with the interment of deceased individuals. In one embodiment, funeral service providers serve as a front end for taking orders for subscriptions to a third-party gravesite location information service. The invention also provides methods and systems for finding a selected gravesite using satellite or terrestrial positioning systems.

Gravesite location information service

The invention provides methods for the identification and discovery of agents which are inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases. The essential feature of the invention is the incorporation of a functional polymerase binding site sequence (PBS) into a nucleic acid molecule which is chosen for its ability to confer a discernible characteristic via its sequence specific activity such that the incorporation of the PBS renders the nucleic acid molecule a functional template for a predetermined RNA or DNA-template directed nucleic acid polymerase (1). In the presence of the polymerase, suitable primer molecules, and any necessary accessory molecules, catalytic extension of the strand of nucleic acids complementary to the template occurs, resulting in a partial or total elimination of (or increase in) the characteristic conferring activity of the reporter-template molecule described due to the antisense effects of the complementary strand or other polymerase-mediated effects. Candidate inhibitors and activators are evaluated for their specific effects on polymerase function, versus polymerase-unrelated effects on reporter-template function, by comparing their ability to decrease or increase the extent of the characteristic conferred by the activity of the reporter-template molecule in the assay to their ability to do so in the control situation in which the activity of the polymerase has been eliminated from the assay. A novel method for controlling gene expression and, in general, the activity of a nucleic acid molecule is also disclosed.

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Fort Lee, NJ, United States of America

Paul Diamond