Sanofi

Sanofi-aventis

Elf Sanofi

Paul De Cointet

Jean-Pierre Maffrand

Dino Nisato

Jean Wagnon

Daniel Frehel

Claudine Serradeil-Legal

Bernard Tonnerre

Pierre Despeyroux

Claude Plouzane

Alain Badorc

Daniele Anne Gully

Danielle Gully

Jean-Marc Herbert

Jean-Pierre Bras

Rebecca Pruss

Eric Bignon

Corinne Heckel

Marie-Francedillaoise Bordes

Chantal Guenet

The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; Rrepresents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C-Calkyl, a C-Calkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; Rrepresents a C-Calkyl group optionally substituted, a C-Ccycloalkyl, piperidinyl or phenyl group, the C-Ccycloalkyl, piperidinyl or phenyl groups being optionally substituted; Rrepresents a hydrogen atom or a C-Calkyl group optionally substituted; Rrepresents a hydrogen atom or a C-C4 alkyl group; and Rand Rrepresent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C-Calkyl group, or Rand Rform together an oxo group; Rrepresents a hydrogen atom, a halogen atom, a C-Calkyl, a C-Calkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy 

Acylaminothiazole derivatives, their preparation and therapeutic use

The invention relates to the compounds of formula (I) ##STR1## in which R.sub.I, R.sub.II, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are as defined in claim 1.

Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one

The present invention relates to compounds of formula: ##STR1## which are agonists of cholecystokinin receptors and pharmaceutical compositions containing them.

Glycinamide derivatives, processes for their preparation and medicines

Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one

The invention concerns compounds of formula ##STR1## in which R, A, R.sub.1 and Y are as defined in claim 1. The instant compounds have an affinity for the fibrinogen receptor: the complex of the glycoproteins IIb/llIa (GP IIb/IIIa); more particularly, the subject of the present invention is new inhibitors of platelet aggregation which are antagonists of the GP IIb/IIIa receptors, of nonpeptide structure, which are active via the parenteral and oral routes.

Substituted 4-phenylthiazole derivatives, process for their preparation

The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors.

N-sulfonylindoline derivatives, their preparation and the pharmaceutical

The invention relates to N-sulfonyl derivatives of formulae (I)' and (I)' ##STR1## and to pharmaceutical compositions in which they are present. The compounds have an affinity for the vasopressin and ocytocin receptors.

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Toulouse, France

Paul De Cointet