National Institutes of Health, a Component of the US Dept. of Health & Human Services

The United States of America As Represented by the Department of Health

Angle Europe Limited

USA As Represented by Secretary of the Navy

The United States of America As Represented by the Secretary of

Eriez Manufacturing Co.

The Government of the United States of America, As Represented by the

Progenity, Inc.

Ngimat Co.

Axela Inc.

Paul D Smith

Robert F Bonner

Seth R Goldstein

Thomas J Pohida

Alexandre M Izmailov

John I Peterson

Walter S Friauf

Frank S Harrington

Brian Pak

Lance A Liotta

David B Krizman

Michael R Emmert-Buck

W Marston Linehan

Rodrigo F Chuaqui

Tomoyuki Sen

McClellan M Walther

Jeffry M Trent

Thomas F DeLaney

Eric F Bernstein

Edward Wellner

David Englert

Andrew Tye Hunt

Mitchell Lawrence Jones

Roy W Rice

James B Mitchell

Christopher Loren Wahl

William John Dalzell, Jr

Albert Claude Boccara

Mark S Mirotznik

Sankaran Subramanian

Bradley Allen Roth

Amir H Gandjbakhche

Rolf G Tschudin

Murali K Cherukuri

Victor Chernomordik

Robert C Pohanka

James Jukkola

Mark Batich

Nicole Y Morgan

Steven S Lee

Joseph F Fessler

Paul G Zablocky

John Bourg

Peter W Faguy

Basil E Walker

Alexander Sviridov

Stein S Lee

William Harm

Zachary Ulissi

Joanne Yardlyne Smalley

William Hoos

John Mitchell McLean

Francisco De Monasterio

Ed Wellner

John W Cole

Roger E Solomon

John Cole

Moinuddin Hassan

Charles McKendrie Quillian, V

Jorge L Juncos

Frank C Witbrod

Patrick Davis

An apparatus for grasping and propping electronic devices is an apparatus that enables users to easily handle a portable electronic device with one hand or to prop the device on a surface for comfortable viewing of the device's screen. The apparatus can be utilized with tablet computing devices but can also be utilized with other electronic devices. The apparatus includes an oblong base, a propping leg, a hand strap, and an attachment mechanism. The oblong base receives the body of the electronic device when the apparatus is attached to the backside of the electronic device or to a device accessory. The propping leg enables the apparatus to be utilized as a stand for the electronic device. The hand strap enables the apparatus to be utilized as a hand holder for the electronic device. The attachment mechanism enables the apparatus to be easily and releasably attached to the electronic device.

Apparatus for grasping and propping electronic devices

The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation. Post centrifugation the first cap is removed and a fluid absorbing element and cap, designed to provide controlled removal of the liquid and to prevent positioning of a tip of the absorbing element to a distance from the solid support shorter than a predefined distance is inserted into the fluid chamber.

Cell recovery method and device

The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.

A system for metal detection comprises a single aperture comprising two or more sets of detection coils that surround the perimeter of the aperture. A flow path of materials passes through the aperture. Each set of detection coils comprises a transmitter and two receiver coils, with the transmitter coil located between the two receiver coils. Each set of detection coils is at a different angle relative to the flow path.

Metal detector coil configuration to eliminate orientation effect

The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.

Disposable bioassay cartridge and method of performing multiple assay steps and fluid transfer within the cartridge

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

Gastrointestinal tract detection methods, devices and systems

The present disclosure provides a diffraction based biosensor containing at least two diffraction gratings. The first grating is referred to as an in-coupling diffraction grating and the coherent light source (laser) is directed to illuminate the in-coupling grating, and the biosensor is configured such that a selected order of the light beam diffracted from the in-coupling diffraction grating illuminates a second biosensor grating coated with analyte-specific receptors which are selected to preferentially bind with analytes being tested for that may or may not be located in a sample being tested.

Diffraction based biosensor containing two diffractive gratings

A polarization-based colposcopy apparatus includes a polarization exchanging beam splitter pair oriented so that s- and p-polarizations are exchanged. An optical flux from a specimen is directed through the pair, and orthogonal components thereof are alternately or selectively coupled to an array detector. The detected images are processed based on image correlations to reveal specimen structures.

Polarimetric accessory for colposcope

An eye examination device has a fundus observation system and an optical stimulation system. The optical stimulation system has an optical targeting subsystem and an optical stimulation subsystem, wherein the optical stimulation system is structured to be used to provide light stimulation to a portion of a fundus of an eye targeted by the optical targeting subsystem in conjunction with observations made with the fundus observation system.

Fundus photo-stimulation system and method

To form an ionomer-based catalytic layer on a porous substrate, a heat source () is used to dry an ionomer-containing spray () so that it does not substantially liquid flow on the substrate (). The ionomer spray () may contain a catalyst. A spray () of mixed material for forming the catalytic layer is entrained by a gas stream and is heated and directed to a substrate surface (). For hydrogen/oxygen fuel cells, catalytic material is incorporated into the proton-conducting membrane () to convert diffusing oxygen and hydrogen to water to reduce potential loss at the electrodes and maintain hydration of the proton-conducting membrane ().

Fuel cell membranes and catalytic layers

Laser capture microdissection occurs where the transfer polymer film is placed on a substrate overlying visualized and selected cellular material from a sample for extraction. The transfer polymer film is focally activated (melted) with a pulse brief enough to allow the melted volume to be confined to that polymer directly irradiated. This invention uses brief pulses to reduce the thermal diffusion into surrounding non-irradiated polymer, preventing it from being heated hot enough to melt while providing sufficient heat by direct absorption in the small focal volume directly irradiated by the focused laser beam. This method can be used both in previously disclosed contact LCM, non contact LCM, using either condenser-side (or beam passes through polymer before tissue) or epi-irradiation (or laser passes through tissue before polymer). It can be used in configuration in which laser passes through tissue before polymer with and without an additional rigid substrate. In its preferred configuration it uses the inertial confinement of the surrounding unmelted thermoplastic polymer (and the overlying rigid substrate) to force expansion of the melted polymer into the underlying tissue target. Utilizing the short pulse protocol, the targeted and extracted material can have a diameter equal to or smaller than the exciting beam.

Method of laser capture microdissection from a sample utilizing short pulse length

A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated. During separation, the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample, the zone of cells of interest may then be molecularly analyzed.

Isolation of cellular material under microscopic visualization

A tissue sample is conventionally visualized in a microscope. A selectively activated convex surface is provided, preferably at the distal end of a rod. This selectively activated convex surface when activated, typically with a laser through an optic light path in the microscope, provides the activated region with adhesive properties. At least one portion of the tissue sample which is to be extracted is identified. This identified portion is contacted with a portion of the selectively activated convex surface on the end of the rod. When the convex surface is activated, typically by exposure to laser light in the footprint of the desired sample, an adhesive transfer surface on the selectively activated convex surface is provided which adheres to the desired cells in the footprint of the desired sample. Thereafter, the adhesive transfer surface is separated from the remainder of the tissue sample while maintaining adhesion with the desired cells. Thus the desired portion of the tissue sample is extracted. The disclosed selectively activated convex surface is preferably utilized to collect desired tissue samples at more than one location on the same slide or from different slides. The collected tissue samples can thereafter be inspected if desired, as collected on the convex surface, and then liberated&mdash;as by dissolving the proteins of the samples. This can effectively concentrate rarely occurring cells in order to obtain enough pure material for analysis. A rod having a convex surface with the selectively activated material is set forth as a staple for use with the apparatus and process. Preferred shapes for the convex surface are disclosed as well as a method for coating rods with a resultant rod article.

Convex geometry adhesive film system for laser capture microdissection

Growing community of inventors

Annapolis, MD, United States of America

Paul D Smith