Bristol-myers Company

Paul D Sleezer

David A Johnson

Jeng S Lin

Richard R Smith

Crude cephalosporin 7-[.alpha.-(2-aminomethylphenyl)acetamido]-3-[(1-carboxymethyltetrazol-5-y lthio)methyl]-3-cephem-4-carboxylic acid is purified by converting it to its salt with benzyldimethylamine, recovering said salt and from it regenerating said cephalosporin in purified form.

Purification of ceforanide

A new esterifying agent, i.e. methoxymethyl tosylate, is provided for use in preparing methoxymethyl esters of organic carboxylic acids. The new esterifying agent is found to be particularly advantageous in the esterification of penicillin 3-carboxyl groups or cephalosporin 4-carboxyl groups to the methoxymethyl ester group.

Esterification process using methoxymethyl-P-toluenesulfonate

Methoxymethyl p-toluenesulfonate

There is disclosed a process for preparing methoxymethyl 6-aminopenicillanate, its conversion to methoxymethyl amoxicillin and the use of the latter compound as an intermediate in the preparation of the methoxymethyl ester of p-hydroxyhetacillin which is the preferred product of this invention.

Methoxymethyl

The specification discloses a process for preparing methoxymethyl D-6-(2,2-dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)penicillanate and the use of this compound as a well absorbed antibacterial agent and also as an intermediate in the preparation of other antibiotic derivatives of 6-aminopenicillanic acid such as hetacillin. The methoxymethyl ester of ampicillin is also disclosed.

Growing community of inventors

Dewitt, NY, United States of America

Paul D Sleezer