Pcr, Inc.

Optical Polymer Research, Inc.

Paul D Schuman

Roy Anderson

Geraldine Westmoreland

Paul Tarrant

Dale A Warner

Patrick Laughlin Kelly

Ralph J DePasquale

Ralph J De Pasquale

Raja Mani

A process for preparing optical fiber cladding solutions starting with a monomer having the formula

Process for preparing optical fiber cladding solutions

Curable optical fiber cladding compositions that exhibit improved optical, mechanical, adhesive and moisture barrier properties are prepared from a 100% reactive composition of monofunctional and multi-functional monomers. The preferred components of these compositions are low molecular weight polymers of fluorine-containing monofunctional acrylate or methacrylate monomer(s), such polymers being soluble and dissolved in a fluorocarbon acrylate or methacrylate monomer or monomers, but not necessarily those of the base polymer. The preferred cladding compositions may be prepared with or without a cross-linking monomer such as a di-functional or poly-functional acrylate of methacrylate. The claddings may also use a thermal or photoinitiator or other known polymerization initiating system and an adhesion promoter or promoters, such as acrylic or methacrylic acid, a silanol acrylate, methacrylate, alkoxysilane acrylate or methacrylate, or an alkoxy vinyl silane, aryl acrylate or methacrylate.

Curable inter-polymer optical fiber cladding compositions

A process for preparing 5-fluorouracil, and a novel starting compound for such process, are disclosed. The novel starting compound is 2,4,5-trifluoropyrimidine. The process comprises hydrolyzing the 2,4,5-trifluoropyrimidine at a temperature of about 2.degree. to about 100.degree. C., thereby directly producing the compound 5-fluorouracil. 5-Fluorouracil is a known anti-tumor agent, which has been used in the treatment of various types of cancers. In addition, 5-fluorouracil is a starting material for the production of certain types of pro-drugs, which are metabolized to form 5-fluorouracil in the body, such as, for instance, the compound 1-(2-tetrahydrofuryl)-5-fluorouracil.

Process for making 5-fluorouracil

A process for preparing 5-fluorouracil, and a novel starting compound for such process, are disclosed. The novel starting compound is 2,4,5-trifluoropyrimidine. The process comprises hydrolyzing the 2,4,5-trifluoropyrimidine at a temperature of about 2.degree. to about 100.degree. C., thereby directly producing the compound 5-fluorouracil. 5-fluorouracil is a known anti-tumor agent, which has been used in the treatment of various types of cancers. In addition, 5-fluorouracil is a starting material for the production of certain types of pro-drugs, which are metabolized to form 5-fluorouracil in the body, such as, for instance, the compound 1-(2-tetrahydrofuryl)-5-fluorouracil.

2,4,5 Trifluoro pyrimidine and process for preparing

Direct fluorination of uracil, cytosine and their derivatives, in the presence of a non-aqueous solvent, by fluorine gas to produce 5-fluorouracil, 5-fluorocytosine, 5-fluorouracil derivatives and 5-fluorocytosine derivatives is disclosed. The non-aqueous solvent is an acid or alcohol, which can be partly or fully fluorinated or chlorinated, of up to 8 carbon atoms, such as trifluoroacetic acid. Novel compounds produced by the reaction, such as 5,5-difluoro-5,6-dihydro-6-(2,2,2-trifluoroethoxy) uracil are also disclosed. The derivatives and 5-fluorocytosine are useful as germicidal and antineoplastic agents while 5-fluorouracil itself is a known cancer chemotherapy agent.

5,5-Difluorouracil

Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.

5-Fluorouracil derivatives

Process for producing 5-fluorouracil and derivatives thereof in acid

A process for producing bis-silyl derivatives of fluorinated pyrimidines is disclosed, wherein a 5-fluoro-6-hydroxy or alkoxy pyrimidine is reacted with a silane, such as triethylchlorosilane. The intermediate product produced by that reaction, which is obtained in high yield, may then be reacted with a further compound, which can be a blocked sugar halide or 2-chlorotetrahydrofuran, to produce a nucleoside of the pyrimidine. The nucleosides are useful as antibacterial and antiviral agents, and in the treatment of cancer.

Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine

Process for fluorinating uracil and derivatives thereof

The reaction of certain fluorinated pyrimidine derivatives with hydrogen donor compounds to produce 6-substituted 5-fluoropyrimidines is disclosed. The products so produced are useful in germicidal and antineoplastic applications, and can be converted into 5-fluorouracil, which has known utility in cancer chemotherapy.

Growing community of inventors

Hawthorne, FL, United States of America

Paul D Schuman