Bristol-myers Squibb Compnay

Paul D Pansegrau

Michael A Poss

Richard H Mueller

Janak Singh

Shaopeng Wang

John K Thottathil

John K Thottahil

The present invention relates to novel 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates which may be used to prepare a final anti-thrombotic, anti-vasospastic product, and to methods for preparing the same.

7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates

A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##

7-Oxabicycloheotane carboxylic acid prostaglandin analog intermediates

7-oxabicycloheptane carboxylic acid protaglandin analog intermediates

A method is provided for preparing carboxylic acid intermediates of the structure ##STR1## wherein an aldehyde of the structure ##STR2## is prepared and subjected to a Horner-Emmons reaction to form the ester of the structure ##STR3## and the ester is hydrogenated to the carboxylic acid which may be used in making the final anti-thrombotic--anti-vasospastic compounds.

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E. Windsor, NJ, United States of America

Paul D Pansegrau