Johns Hopkins University

Genzyme Corporation

Avigen, Inc.

Other

Bristol-myers Squibb Compnay

Nabi Biopharmaceuticals, Inc.

Genvec, Inc.

Paul D Kessler

Gary J Kurtzman

Gregory M Podsakoff

Barry J Byrne

William R Ewing

Ali Ibrahim Fattom

Karen W Chu

Matthew W Kalnik

Elyse G Stock

Leslie Hudson

Maria Borentain

Henrik S Rasmussen

Matthew Hohenboken

Tushar Garimella

Raafat Fahim

The disclosed subject matter provides methods of using nitroxyl donating compounds and pharmaceutical compositions comprising such compounds in a dose escalation regimen.

Method of administering nitroxyl donating compounds

Described are smoking cessation devices and kits for determining an advantageous time for a subject to quit smoking, and/or for extending the duration of smoking abstinence, based on serum levels of anti-nicotine antibodies. Related methods are also described.

Smoking cessation kit and method

The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue in the treatment of anemia is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of a delivered nucleotide sequence encoding erythropoietin, and for in vivo secretion thereof from transduced muscle cells such that systemic delivery is achieved.

Methods of treating anemia using recombinant adeno-associated virus virions

The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved.

Methods for delivering DNA to muscle cells using recombinant adeno-associated virus virions

Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors

Adeno associated virus vectors for the treatment of a cardiomyopathy

Methods for delivering DNA to muscle cells using recombinant adeno-associated virus virions to treat lysosomal storage disease

Methods for delivering DNA to the bloodstream using recombinant adeno-associated virus vectors

Adeno-associated virus vectors comprising a gene encoding a lyosomal

Methods for delivering DNA to muscle cells using recombinant

Growing community of inventors

Hagerstown, MD, United States of America

Paul D Kessler