Obalon Therapeutics, Inc.

Amgen Inc.

Reshape Lifesciences Inc.

Hewlett-packard Development Company, L.p.

Hewlett-packard Company

Biolinq Incorporated

Global Bio Therapeutics, Inc.

Belon Engineering, Inc.

Paul D Faucher

Mark C Brister

Dubravka Markovic

Neil R Drake

Antonio C Llevares

Andrew P Rasdal

Amy D L VandenBerg

Matthew S Lake

Josefina Nider

Mehran Mojarrad

Scott Robert Gibson

Stephan Walter Emmenegger

Michael Gustafson

Sheldon B Moberg

Daniel Eduardo Groszmann

Joshua Tamsky

Nitish Swarup

David Michael Morelock

Hsin-Chih Chen

Lawrence Scott Ring

Allan G Olson

Adam B McCullough

David W Leong

John N Hoffman

George Albert Mansfield

Wael Mismar

Erich E Coiner

Allan Rozenberg

Antonio Ubach

Juan Bautista Belon

Sudeshna Dutta Ray

Steven Masterson

Curtis Gregory Kelsay

Ali Nekouzadeh

Jimmie L Ward

Matthew Wayne Janke

Joshua Andrew Warner

William Wistar Rhoads

Nathan Thomas Balcom

Joshua David Doan

Jose Gustavo Cabrera Aquino

Mikhail Tikh

Blanca Angelica Segura Pacheco

Robert Allen Dees

Samin Akbari

Tohid Pirbodaghi

David Meyer

Jeff Lind

Susan McConnell Montalvo

Matthew Pacheco

Ed Maher

Shu-Hsun Chiang

Mark Gordon

John K Hoffman

Ya-Fang Ke

Hsing-Han Tsai

Chia-Wen Chang

Amy D L Vandenberg

Amy D I Vandenberg

Amy DL Vandenberg

Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, monitoring, and retrieving the same are provided.

Intragastric device

A wearable drug delivery device includes a housing, a needle assembly at least partially disposed in the housing, and a drive assembly at least partially disposed in the housing and coupled to the needle assembly. The needle assembly includes a needle or cannula and a sterile barrier disposed proximal to the needle or cannula in a first configuration where the sterile barrier is intact. The drive assembly includes a container that contains a medicament to be administered, a first plunger disposed in the container, and a drive mechanism that forces the first plunger to urge the medicament through the container. Upon engaging the drive mechanism, the needle or cannula and the sterile barrier move relative to each other from the first configuration to a second configuration where the needle or cannula breaks the sterile barrier, thereby allowing the medicament to be administered via the needle or cannula.

Hydraulic-pneumatic pressurized chamber drug delivery system

Fluid path assemblies for drug delivery devices and methods of establishing a fluid flow path for drug delivery devices are described that include a needle shield valve member that couples to a reservoir having a needle mounted thereto. The needle shield valve member includes an internal barrier that protects the needle and/or contains a drug within the reservoir until activation of the drug delivery device. Upon activation, there is relative movement between the reservoir and needle shield valve member until the needle pierces the barrier to establish a fluid flow path from the reservoir through the needle shield valve member.

Fluid path assembly for a drug delivery device

Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.

Drug delivery system with flexible piston assembly

A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.

Backflow prevention mechanism for drug delivery device

An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device

Infusion pump

An insertion mechanism for a wearable drug delivery device that deploys a small gauge flexible cannula with support of a coaxial rigid trocar or hollow needle. After insertion, the trocar or hollow needle is withdrawn leaving the cannula in place for drug delivery. The insertion mechanism may also include an insertion mechanism housing having a proximal and distal end, a manifold configured to fluidly connect the hollow interior of the cannula and the fluid pathway connector, and a manifold guide carrying the manifold and movable between a first position and a second position. A hub carries the trocar and is removably connected to the manifold guide. An insertion biasing member may be initially retained in an energized state between the proximal end of the insertion mechanism housing and the hub, and a retraction biasing member may be initially retained in an energized state between the hub and the manifold guide.

Cannula insertion and retraction mechanisms

Provided herein is a clamp device that can be used in minimally invasive procedures, including surgeries such as laparoscopic surgeries, for clamping a tissue or an organ or a portion of a tissue or organ. Also provided herein are methods of clamping a tissue or an organ or a portion thereof during minimally invasive surgery using the clamp device provided herein. Also provided are systems for performing a minimally invasive surgery that include the clamp device for minimally invasive surgery provided herein and an injection device configured to access an endoscopic port for the minimally invasive surgery.

Clamp device for minimally invasive procedures and uses thereof

Growing community of inventors

Escondid, CA, United States of America

Paul D Faucher