Zymogenetics, Inc.

Other

University of Kentucky Research Foundation

Baxter International Inc.

Mcmaster University

Mallinckrodt Pharma IP Trading D.a.c.

Novo Nordisk A/s

Paul D Bishop

Paul O Sheppard

Gerald W Lasser

Theresa A Deisher

Peter R Oeltgen

Stephen R Jaspers

Mark S Kindy

Nand Baindur

Christopher S Piddington

Steven D Hughes

Richard I Senderoff

Jeffrey D Meyer

Richard M Garcia

Emily N Rollins

Juan A Sanchez

Virender M Labroo

Fraser D Rubens

James Boyd Shaible

Craig J McClain

Shirish Barve

Alisa M Littau

Steven R Carter

William Allan Alexander

Thomas R Bukowski

Christopher K Raymond

David W Taft

Robert R West

Angelika Grossmann

Lynn Massman Rose

Tracey A Pownder

Angelika Grossman

Christopher J Stenland

Birgitte Ro Rassing

Jin-Jyi Chang

Kenneth B Lewis

Jan Öhrström

Mads Laustsen

Teresa Martinez

Hank R Franklin

Steve R Carter

James Boyd Schaible

Paul A Brown

Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.

Hemostatic microspheres

An improved handrail for a staircase or ramp. In one embodiment, the handrail includes an elongated member such as a cylinder or bar that spans the length of the staircase or ramp and a riser barrier. The riser barrier has an extender portion and a riser portion. The extender portion of the riser barrier keeps the elongated member a sufficient distance horizontally from the riser portion that a person can slide his or her hand on the rail without interference. The riser portion projects vertically a sufficient distance above the elongated member to deter sliding down the elongated member. Thus, sliding on the member is deterred, while the function of the cylinder as a handrail is preserved.

Handrail for staircase or ramp

Provided is a surgical applicator and applicator tip configured to attach in fluid communication, for the delivery of beneficial fluids. The applicator tip may also be configured to reversibly attach, in fluid communication, with a pledget. For example, the applicator tip may include male or female threads, and the pledget has threads that are complementary to the thread configuration of the tip. The applicator tip may further comprise at least one fluid transfer lumen for transfer of a fluid from the tip to the pledget. In one embodiment of the invention, the tip includes male threads and the pledget includes a pledget attachment portion. There are also provided methods for connecting the tip to the pledget. In one embodiment, a tip comprising male threads is attached to the pledget, comprising a pledget attachment portion, by tapping or pressing the tip into the pledget attachment portion. There are also provided methods of use for the attached tip and pledget, including debridement, tissue translocation, delivery of fluid substances, absorption of fluid substances and combinations thereof. In a particular embodiment, the applicator places a thrombin solution into the attached pledget for delivery of an active hemostatic agent to a tissue site.

Medical devices for delivering fluids during surgery and methods for their use

Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.

Thrombin activator compositions and methods of making and using the same

The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.

Methods of using motilin homologs

The present invention provides polypeptides and compositions comprising amino acid residues 23 to 108 of SEQ ID NO: 2, polypeptides and compositions comprising amino acid residues 28 to 108 of SEQ ID NO: 2, including affinity tags and the like, useful for stimulating gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis.

Human Zven polypeptides

The present invention provides a new family of human proteins, designated as 'Zven,' as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis. The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

Human zven polynucleotides

The present invention provides novel uses two members of a new family of human proteins, designated as 'Zven,' as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The invention also provides methods for using the antibodies to detect the presence of the protein with antibodies and methods for using the polynucleotides to detect the presence of Zven RNA.

Method of using Zven antibodies

Game controller unit for an exercise system

Growing community of inventors

Fall City, WA, United States of America

Paul D Bishop