Merck Patent Gmbh

Paul Czodrowski

Christos Tsaklakidis

Dieter Dorsch

Lars Thore Burgdorf

Christina Esdar

Margarita Wucherer-Plietker

Mathilde Muzerelle

Wolfgang Staehle

Markus Klein

Hans-Michael Eggenweiler

Guenter Hoelzemann

Thomas Fuchss

Birgitta Leuthner

Brigitta Leuthner

Compounds of the formula I in which X, X, X, X, R, R, R, Q and Y have the meanings indicated in claimare inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

Quinolin-2-one derivatives

Compounds of the formula I in which X, X, X, X, R, R, R, Q and Y have the meanings indicated in Claimare inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.

Acylguanidines for treating osteoarthritis

3-aminocyclopentane carboxamide derivatives

Compounds of the formula I in which R, R, R, R, X, X, X, X, q and W have the meanings indicated in claimare inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

1,3-diaminocyclopentane carboxamide derivatives

Compounds of the formula (I) in which R, R, X and Y have the meanings indicated in claim, are inhibitors of TBK1 and IKK&#x3b5; and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives

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Friedberg, Germany

Paul Czodrowski