Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Merck Patent Gesellschaft MIT Beschrankter Haftung

Assistance Publique-hopitaux De Paris

UniversitÉ Paris Descartes

Sarl Endocells

Univercell Biosolutions

Animal Cell Therapy - Act

Paul Czernichow

Philippe Ravassard

Michel Polak

Raphaël Scharfmann

Maryam Asfari

Raphaeel Scharfmann

The present invention relates to a method for preparing commercial scale quantities of canine functional beta cells and to the establishment of cell lines from immature canine pancreatic tissues. It also relates to a method of diagnosis using canine beta cell tumours or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating beta cells, allowing generating canine Beta cell lines. Such lines express, produce and secrete insulin upon glucose stimulation.

Production of a canine beta cell line from an immature pancreas

The present invention relates to a method for preparing commercial scale quantities of human functional Betacells and to the establishment of cell lines. It also relates to a method of diagnosis using Beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating Betacells, allowing to generate human Betacell lines. Such lines express little amount of insulin and have a gene expression profile that resembles to adult Betacells. In addition, the human Betacell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.

Human pancreatic beta cell lines for diagnostic of diabetes

The present invention relates to a method for preparing commercial scale quantities of human functional beta cells and to the establishment of cell lines from non-foetal pancreatic tissues. It also relates to a method of diagnosis using beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating beta cells, allowing to generate human Beta cell lines. Such lines express, produce and secrete insulin upon glucose stimulation. They have a gene expression profile that resembles to adult beta cells. In addition, the human beta cell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.

Production of a human beta cell line from an early post natal pancreas

The present invention relates to compositions and methods for treating diabetes mellitus, neuropsychological and neurological disorders in a particular group of patient. More specifically, the invention relates to methods of treating diabetes mellitus, neuropsychological and neurological disorders in patients having defective potassium channels. The invention may be used in human subjects, particularly adults or children, and is appropriate to treat various neurological disorders.

Compositions and methods for treating diabetes and neuropsychological dysfunction

Insulin-secreting cell lines, methods of production and use

Growing community of inventors

Paris, France

Paul Czernichow