Ucb Societe Anonyme

Paul Croisier

Ludovic Rodriguez

Ludovic Rodriquez

New physiologically active 1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones having the general formula ##STR1## wherein R.sub.1 is hydrogen or phenyl, R.sub.2 is hydrogen, alkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.1 -C.sub.4 -acyl, hydroxyalkyl, alkoxyalkyl, mono- or dialkylaminoalkyl, cyanoalkyl, alkoxyacetyl, carbamoylalkyl, acetamido-C.sub.2 -C.sub.5 -alkyl, alkoxycarbonylalkyl or (tetrahydro-2H-pyran-2-yloxy)alkyl, the alkyl and the alkoxy radicals having 1 to 5 carbon atoms, R.sub.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl, R.sub.7 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkoxy and R.sub.8 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkyl, at least one of the symbols R.sub.1 to R.sub.8 being other hydrogen, processes for the preparation thereof and pharmaceutical compositions containing the same. In particular, the compounds of this invention are useful in the treatment of memory disorders.

1,2,4,5-Tetrahydro-3H-2-benzazepin-3-ones

New physiologically active 2-carbamoyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones having the general formula ##STR1## wherein R.sub.1 is hydrogen or phenyl, R.sub.2 is morpholino or amino mono- or di-substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl or phenyl, R.sub.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.5 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.7 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkoxy, R.sub.8 is hydrogen, halogen or C.sub.1 -C.sub.4 -alkyl, processes for the preparation thereof and pharmaceutical compositions containing the same. In particular, the compounds of this invention are useful in the treatment of memory disorders.

2-Carbamoyl-1,2,4,5-tetrahydro-3H-2-benzazepin-3-ones

Thieno[3,4-d]pyrimidines of the general formula: ##SPC1## Wherein R.sub.1 is hydrogen, halogen, alkyl, alkoxy, amino, alkylamino, allylamino, hydroxy-alkylamino, cycloalkylamino, phenylamino, dialkylamino, di(hydroxyalkyl)-amino, alkyl-hydroxyalkyl-amino, pyrrolidino, piperidino, alkylpyrrolidino, alkylpiperidino, morpholino, alkyl-2-morpholino, alkyl-3-morpholino, dialkyl-3,5-morpholino, N-methylpiperazino, all said alkyl having 1 to 7 carbon atoms, said alkoxy having 1 to 5 carbon atoms and said cycloalkyl having 3 to 6 carbon atoms, R.sub.2 has the same meanings as R.sub.1 except alkyl and with the proviso that R.sub.2 is other than hydrogen or halogen, when R.sub.1 represents hydrogen or halogen and R.sub.3 is hydrogen or alkyl having 1 to 7 carbon atoms, as well as the addition salts thereof with pharmaceutically acceptable acids are, in particular, active on the cardiovascular system. Processes for their preparation are given.

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Paul Croisier