Indiana University

Purdue Research Foundation

Paul Critser

Sherry L Voytik-Harbin

Mervin C Yoder

Seth Kreger

Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The building blocks may be isolated by fractionating an acid soluble Type I collagen. The building blocks comprising monomers and/or oligomers may be recombined in desired ratios to alter the matrix microenvironment and to influence ECFC behavior.

Materials and methods for controlling vasculogenesis from endothelial colony forming cells

Collagen based-matrices and methods of their use are described. More particularly, collagen-based matrices for differentiating stem cells and progenitor cells, and for producing and isolating blood vessels and vascularized graft constructs are described.

Growing community of inventors

Indianapolis, IN, United States of America

Paul Critser