Leland Stanford Junior University

Paul Clifford Herrmann

David Alvin Tyvoll

Brian S Bull

James P Collman

Christopher Jeffrey Barile

Richard Decreau

It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.

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Loma Linda, CA, United States of America

Paul Clifford Herrmann