Pfizer Corporation

Paul C Watts

Walter P Cullen

Junsuke Tone

Walter D Celmer

Riichiro Shibakawa

Liang H Huang

Takushi Kaneko

Mark A Guadliana

Charles E Moppett

John B Routien

Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C -C ) alkyl or CH (CH ) CO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H antagonist, colloidal bismuth subcitrate and other antibiotics.

Compounds for treating gastroduodenal diseases

Spirolaxine derivatives for treating gastrobuodenal diseases

Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3',4'-di-O-acetylerythromycin D, 3'-O-acetyl-4'-O-propionylerythromycin D and 4'-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.

Erythromycin D and esters thereof by fermentation with Nocardia sp. ATCC

Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3',4'-di-O-acetylerythromcyin D, 3'-O-acetyl-4'-O-propionylerythromycin D and 4'-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.

Erythromycin D and esters thereof

A species of Nocardia, designated Nocardia argentinensis Huang ATCC 31438, when subjected to aerobic submerged fermentation, produces an antibiotic complex containing as its major component antibiotic Compound 51,467. Methods for the recovery and purification of antibiotic Compound 51,467 and minor antibiotic components, Compounds 52,726 and 52,748, and some of their properties are outlined.

Antibiotics produced by species of Nocardia

A new sulfur-containing polypeptide antibiotic produced by two strains of Streptosporangium under submerged fermentation conditions is useful for the treatment of microbial infections and in improving feed utilization efficiency in ruminants.

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Mystic, CT, United States of America

Paul C Watts