Scimed Life Systems, Inc.

Target Therapeutics, Inc.

Medtronic, Inc.

Boston Scientific Scimed, Inc.

Stryker Corporation

Stryker Nv Operations Limited

Paul C Slaikeu

Robert M Abrams

Joseph Charles Eder

Paul H Burmeister

Steven S Hackett

Richard E Cappetta

James J Barry

Michael P Wallace

James R Keogh

Clifford Teoh

Michael Jay Ebert

Allan H Jevne

Hanh Ho

Kenneth E Cobian

Richard L Molacek

Kenneth W Quan, Jr

Henry Nita

Paul J Buscemi

Stanley W Olson, Jr

Robert Hergenrother

Quang Q Tran

Marlowe E Patterson

Stanley W Olsen, Jr

Robert James Boock

Sangsoo Park

A vaso-occlusive device is disclosed. The device includes a vaso-occlusive member having a coating disposed thereon. In accordance with one embodiment, the coating comprises a polyacrylic material. In accordance with another embodiment, the coating comprises a polyvinyl alcohol-based material. In accordance with other embodiments, various other materials and coatings are applied to at least a portion of a vaso-occlusive device.

Bioactive components for incorporation with vaso-occlusive members

A guide wire, and a method for the manufacture thereof, having a core and a plastic jacket enclosing the core. The plastic jacket comprises a proximal portion formed of a first plastic material and a distal jacket portion formed of a second plastic material. The distal end of the proximal jacket portion and the proximal end of the distal jacket portion substantially abut each other and are of substantially equal outer diameters so as to form a smooth transition between the proximal and the distal jacket portions.

Intravascular guide wire and method for manufacture thereof

A guide wire, and a method for the manufacture thereof, having a core and a plastic jacket enclosing at least a portion of the core. In some embodiments, the plastic jacket comprises a proximal portion formed of a first plastic material and a distal jacket portion formed of a second plastic material. In some embodiments, the core member has a proximal portion and a distal portion, and a first plastic jacket is disposed about the proximal portion and a second jacket formed of a fluoroelastomer is disposed about the distal portion.

A guide wire, and a method for the manufacture thereof, having a core and a plastic jacket enclosing at least a portion of the core. In some embodiments, the guidewire also includes a radiopaque coil disposed about a first portion of the core wire. The polymer jacket includes a first portion disposed about the radiopaque coil, and a second portion adjacent the first portion and overlaying and in contact with a second portion of the core wire. In some embodiments, the plastic jacket comprises a proximal portion formed of a first plastic material and a distal jacket portion formed of a second plastic material.

One aspect of the present invention pertains to an implantable medical device for at least partially obstructing a neck portion of a vascular aneurysm. The device includes an occlusion subassembly comprising a base section and at least one lateral protrusion fixedly attached to the base section. A therapeutic agent is disposed upon at least one portion of at least one lateral protrusion.

Bioactive three loop coil

This is an implantable medical device assembly for use in surgical procedures. It is most preferably an implantable structure having stenting properties but only partially coated with or partially associated with a material causing a localized angiogenic response. One variation of is an artificial occlusion kit having the inventive implantable stenting structure situatable and vaso-occlusive devices. The implantable stenting structure is typically situated so to prevent migration of artificial occlusion devices or implants from an occlusion site, such as an aneurysm, and into an adjacent body space, such as a blood vessel.

Bioactive aneurysm closure device assembly and kit

This invention is to a minimally invasive surgical device. In particular, the invention relates to an infusion catheter which may be used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vasoocclusive agents to a target site accessible through the vasculature. The device is a flow-directed infusion catheter having a variety of sections of different flexibilities with tapered junctions between those sections. The inventive catheter is directed to that target site by a flow of blood to the site.

Flow-directed catheter

A guide wire, and a method for the manufacture thereof, having a core and a plastic jacket enclosing the core. The plastic jacket comprises a proximal portion formed of a first plastic material and a distal jacket portion formed of a second plastic material. The distal end of the proximal jacket portion and the proximal end of the distal jacket portion substantially abut each other and are of substantially equal outer diameters so as to form a smooth transition between the proximal and the distal jacket portions. According to another aspect, there is provided a guide wire with a selectively formable metallic core and a plastic jacket encasing the formable core. The plastic jacket has a distal portion with a hydrophilic coating and a proximal portion without a hydrophilic coating. According to another aspect, there is provided a guide wire having a formable metallic core and a plastic jacket encasing the formable core. The plastic jacket has a distal portion that is more radiopaque than a proximal portion.

A vaso-occlusive device having an inner coating and a water-soluble outer coating. Methods of preparing the devices are also provided.

Water-soluble coating for bioactive vasoocclusive devices

This is a medical device for forming an embolism within the vasculature of a patient. More particularly, it is a vaso-occlusion device at least partially coated with a bioactive agent, a collagenous material, or a collagenous coating optionally containing or coated with other bioactive agents. A highly flexible vaso-occlusive device coated with such materials also forms a variation of the invention.

Bioactive coating for vaso-occlusive devices

This is a medical device for forming an embolism within the vasculature of a patient. More particularly, it is a vaso-occlusion device at least partially coated with a bioactive agent, a collagenous material, or a collagenous coating optionally containing or coated with other bioactive agents. A coated vaso-occlusive device which is highly flexible is also a variation.

This relates to a composition of matter comprising partially hydrolyzed polyvinyl acetate solutions suitable for use as embolic agent precursors. In addition, a procedure for introducing the solutions into the human body to form precipitated embolic occlusion masses is shown. Finally, a procedure for treatment of hepatic tumors using portal vein embolism is described.

Liquid embolic agents

A vaso-occlusive device having a bioactive inner coating and a water-soluble outer coating. Methods of preparing the devices are also provided.

A polymer network useful as a lubricous coating, the polymer network comprising a reaction product of a vinyl prepolymer and an uncrosslinked hydrogel retained within the reaction product such that the network exhibits a greater lubricity when wet.

Growing community of inventors

Belmont, CA, United States of America

Paul C Slaikeu