Johnson Matthey & Co., Limited

Other

Johnson Matthey Public Limited Company

Johnson Matthey Inc.

Paul C Hydes

Donald H Picker

Michael J Cleare

Bernard W Malerbi

James G Heffernan

Harry Middleton

David M Watkins

Derek R Hepburn

Platinum co-ordination compounds comprising at least one amine ligand and a functional group remotely bonded to the amine ligand, which functional group may be linkable to a monoclonal antibody to provide a moiety which stabilizes the antibody against in vivo hydrolysis.

Monoclonal antibody - platinum co-ordination compound complex

Platinum co-ordination compounds

Coordination compounds for use in therapy, the compounds having the general empirical formula

Combination modality cancer therapy

The compound ##STR1## useful for the chemotherapeutic treatment of cancer or malignant neoplasms is provided in substantially pure form by a method of preparation involving a novel intermediate adduct with dimethylacetamide.

Co-ordination compound of platinum

Compositions of matter suitable for the treatment of cancer comprise platinum co-ordination compounds having the general formula ##STR1## in which A is a straight-chain, branched chain or cyclic aliphatic amine, X and Y are halogen and the Z groups are halogen or hydroxy.

Composition of matter containing platinum

This invention relates to the staining of cells, and in particular provides a novel reagent for the detection, for example, of DNA (deoxyribonucleic acid) and polysaccharides by electron microscopy. A reagent for staining cells in accordance with the present invention comprises an aqueous solution of a nitrido-bridged complex of osmium or ruthenium and having the general formula:

Staining with nitrido-bridged osmium or ruthenium compounds

A cis co-ordination compound of platinum having the structure ##STR1## in which X and Y are the same or different ligands selected from sulphate, phosphate, nitrate, carboxylate, halogen-substituted carboxylate and water and A and B are the same or different branched chain aliphatic amines co-ordinated to the Pt through their N atoms, such that the platinum is present as Pt.sup.2+.

Platinum coordination compounds

A coordination compounds of platinum having the Structure: ##STR1## in which R is H or Me and pharmaceutical compositions containing them are disclosed.

Compositions containing platinum

A cis co-ordination compound of platinum having the structure ##STR1## in which X and Y are the same or different ligands selected from halide, sulphate, phosphate, nitrate, carboxylate, carboxylate substituted with halogen and water and A and B are the same or different straight-chain alkyl amines containing at least 3 carbon atoms in the alkyl chain co-ordinated to the Pt through their N atoms, such that the platinum is present as Pt.sup.2+.

A cis co-ordination compound of platinum having the structure ##STR1## in which X and Y are the same or different ligands selected from sulphate, phosphate, nitrate, tartronate, benzylmalonate, cyclobutane-1, 1-dicarboxylate, phthalate, oxalate, tartrate, pyruvate, gluconate, succinato, glutarato, adipato, pimelato and malato and water and A and B are the same or different alicyclic amines selected from cyclopentamine and cyclohexylamine co-ordinated to the Pt through their N atoms, such that the platinum is present as Pt.sup.2+.

A composition of use in compounding an electroplating bath for electrodeposition of gold alloys. The composition contains a nitrosulphite gold complex and at least an alloying agent in the form of a sulphite.

Composition for the electroplating of gold

This specification describes a complex of osmium tetroxide and a compound having a heterocyclic ring containing one or two tertiary nitrogen atoms. The compound may be an aromatic tertiary amine and the tertiary nitrogen atom may be the sole heterocyclic atom in the heterocyclic ring. The complexes described are suitable for fixing and staining cells and may be used in the preparation of biological specimens for examination by electron microscopy.

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Reading, United Kingdom

Paul C Hydes