Elektrofi, Inc.

Massachusetts Institute of Technology

Paul Brown

Chase Spenser Coffman

Lisa Liu

Daniel Benjamin Dadon

Lyndon Fitzgerald Charles, Jr

Sadiqua Shadbar

Chaitanya Sudrik

Sahag Voskian

Cory Robinson

T Alan Hatton

Lyndon Charles

Trevor Alan Hatton

Dale Arlington Thomas, Iii

Shankul Vartak

James W Ivey

Cesar De La Fuente Nunez

Tyler L Carter

Timothy Kuan-Ta Lu

Xianwen Mao

Ryan Alex Shaw

Yi Tang

Jason G Auer

Moin Khwaja

Margarida Fernandes Da Costa Gomes

Paul F Herbert

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof

The present disclosure relates to methods that enable the continuous formation of droplets and dehydration of droplets to provide pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled continuous droplet formation and dehydration that produce circular particles having low internal void spaces comprising bioactive therapeutic biologies.

Methods of forming particles by continuous droplet formation and dehydration

The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

Formation of particles including agents

The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Particle formation and morphology

The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.

Compositions and methods for the delivery of therapeutic biologics for treatment of disease

Disclosed are capacitors containing surface active ionic liquids, and methods of use. The capacitors have high capacitance and function over broad ranges of temperature, and are particularly appropriate for high-temperature (&#x2dc;200&#xb0; C.) applications.

High-temperature supercapacitors containing surface active ionic liquids

The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.

Systems and methods incorporating ionic liquids for electrochemically mediated capturing of Lewis acid gases

Electrospraying formation of particles including agents

Disclosed are polymer-coated surfaces encapsulating task specific ionic liquids (ILs), IL complexes, or oils. Also disclosed are polymer-coated surfaces, wherein the polymer comprises ILs or neutral ethylene diamine compounds. Also disclosed are methods of antimicrobial treatment, metal remediation, and gas absorption using polymer coatings encapsulating ILs, IL complexes, and oils or polymer coatings comprising ILs and neutral ethylene diamine compounds.

Task specific ionic liquid-impregnated polymeric surface coatings for antibacterial, antifouling, and metal scavenging activity

Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.

Silver- and copper-chelating ionic liquids, polymers, and gels, and uses thereof

Systems and methods incorporating ionic liquids for electrochemically mediated capturing of lewis acid gases

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Boston, MA, United States of America

Paul Brown