University of Nebraska

S & P Ingredient Development, LLC

Nutech Ventures

Paul Blum

Derrick White

Sambasiva Rao Chigurupati

Benjamin J Pavlik

Kevin Van Cott

Raghuveer Singh

Microbial cell lines suitable for industrial-scale production of organic acids and methods of making and isolating such cell lines.

Methods for organic acid production

Propionibacterial cell for organic acid production

This disclosure describes methods that allow for the uncoupling of microbial growth from product formation, which allows for maximal use of raw material and optimal end-product formation.

Mutant microorganisms and methods of making and using

An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype oftoxin, while the payload region is derived from a different sub-serotype oftoxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.

Engineered clostridium botulinum toxin adapted to deliver molecules into selected cells

Propionibacterial cell lines for organic acid production

Engineeredtoxin adapted to deliver molecules into selected cells

The present invention is directed to use of hyperthermophilic enzymes for industrial chemical redox reactions such as ethanol production. The present invention is especially useful for the coupled synthesis and recovery of alcohols whereby recovery of alcohol is simplified.

Hyperthermophilic enzymes for industrial chemical redox reactions: a method for biofuel ethanol production

A novel method for examining bacterial growth state is carried out by measuring the levels of conserved cytosolic proteins specific for alternative growth states, using bacterial specific antibody fluorochrome-coupled probe. Utilizing the method of the invention, the cellular growth state of individual bacteria can be determined by measuring the abundance of growth state-specific protein homologs. For example, through use of the protein profiling method of the invention, bacterial VNC state can be distinguished by differentiating growing (exponential phase) from nongrowing or dormant (stationary phase) cells.

Growth state-specific immunofluorescent probes for determining physiological state and method of use

Recombinant, thermostable alpha-glucosidases from archaeal micro-organisms and isolated DNA encoding for such alpha-glucosidases are provided. The isolated DNA is obtained by use of DNA or antibody probes prepared from the DNA encoding alpha-glucosidase. Also provided are methods for producing recombinant archaeal thermostable alpha-glucosidase and transformants incorporating thermostable alpha-glucosidase. Autoprocessing of plant tissue through the use of transgenic thermostable glycosyl hydrolases is described.

Growing community of inventors

Lincoln, NE, United States of America

Paul Blum