Warner-lambert Company

Aquinox Pharmaceuticals Inc.

Paul Bird

Rajeshwar Singh

Joseph P Sanchez

Edmund Lee Ellsworth

Brian Morgan Watson

Dai Q Nguyen

Howard Daniel Hollis Showalter

Michael Andrew Stier

Tuan Phong Tran

Judy Yip

Curtis Harwig

Jeremy D Pettigrew

Vladimir Khlebnikov

Rudong Shan

Dai Quoc Nguyen

Tom MacRury

Sam Place

Noor Aini Bhatti

Howard Daniel Showalter

Joseph Peter Sanchez

Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R, R, R, R, R, Rand Rare as defined herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

SHIP1 modulators and methods related thereto

Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: Rand Rinclude alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, and heteroaryl; R, R, and Rinclude H, alkyl, alkoxy, halo, NO, CN, NH, alkyl and dialkylamino; Rincludes hydrogen, alkyl, cycloalkyl, heterocyclic, fused heterocyclic, aryl and fused aryl; J and K are C or N; and pharmaceutically acceptable salts thereof. 

3-aminoquinazolin-2,4-dione antibacterial agents

Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: Rand Rinclude alkyl, alkenyl, cycloalkyl, aryl, hetero-cyclic, and heteroaryl; R, R, and Rinclude H, alkyl, alkoxy, halo, NO, CN, NH, alkyl and dialkylamino; Rincludes hydrogen, alkyl, cycloalkyl, hetero-cyclic, fused heterocyclic, aryl and fused aryl; J and K are C or N; and pharmaceutically acceptable salts thereof. 

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Edmonton, Canada

Paul Bird