University of Pennsylvania

Paul Bates

James A Hoxie

Michael Endres

Robert Doms

Joseph B Rucker

Trevor L Hoffman

John Balliet

Dennis L Kolson

Yasamin Mir-Shekari

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

Method for the production of antibodies that bind to multiple membrane spanning proteins

Method for the preparation of virus-like particles (VLPS) comprising heterologous multiple membrane spanning proteins

Virus-like particles (VLPs) comprising heterologous multiple membrane spanning proteins

The invention relates to a lipid containing vector capable of fusing to a cell membrane and delivering a compounds contained therein to a cell, and methods of use thereof.

Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery

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Swarthmore, PA, United States of America

Paul Bates