Knoll Aktiengesellschaft

Knoll Aktiengesellachaft

Paul Anthony Bradley

Alan Martin Birch

Roy V Davies

Gerald Bernard Tometzki

Julie Carolyn Gill

Roger Bernard Titman

David George Webber

Michael Henry Hockley

Therapeutic agents

Compounds of formula (I) and pharmaceutically acceptable salts thereof in which A is methylene or &mdash;O&mdash;; B is methylene or &mdash;O&mdash;; G,&mdash;G,&mdash;G,form a heteroaromatic or heteroaliphatic chain; g is 0, 1 or 2; U is an alkylene chain optionally substituted by one or more alkyl; Q represents a divalent group containing nitrogen atoms; and T is an optionally substituted aryl or heteroaryl group, have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, Parkinson's disease, obesity, hypertension, Tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, obsessive-compulsive behavior, panic attacks, social phobias, eating disorders and anorexia, cardiovascular and cerebrovascular disorders, non-insulin dependent diabetes mellitus, hyperglycaemia, constipation, arrhythmia, disorders of the neuroendrocrine system, stress, and spasticity.

Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them

Dioxino derivatives and their use as therapeutic agents

Heteroarylcarboxamide derivatives for treating CNS disorders

A compound of the formula (I), ##STR1## as defined in the specification, having immunomodulatory activity, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the compound, and processes to make and to use the compound are described.

Azolyl-cyclic amine derivates with immunomodulatory activity

Growing community of inventors

Nottingham, United Kingdom

Paul Anthony Bradley