Bristol-myers Squibb Compnay

Cambrex Charles City, Inc.

Salsbury Chemicals, Inc.

Paul Alan Jass

John J Venit

Keith Ramig

Jason Scott Douglas

Ramesh N Patel

Ronald L Hanson

Sushil K Srivastava

John L Dillon, Jr

Mark D Schwinden

Saibaba Racha

Wen-sen Li

David R Kronenthal

Laszlo J Szarka

Jollie D Godfrey, Jr

Nachimuthu Soundararajan

Steven L Goldberg

Gerald L Powers

Atul S Kotnis

Mary Jo Donovan

Matthew Wendell Schiesher

Greg S Buenger

William John Winter

Jerome L Moniot

Shawn K Pack

James H Simpson

Shankar Swaminathan

Erik T Michalson

Chien-Kuang Chen

Todd Jeffrey Johnson

Kezia Peixoto Schutz

The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.

Methods and compositions for preparation of amphetamine conjugates and salts thereof

The present invention relates to a process for the preparation of piperidine derivatives including sufentanil, and their pharmaceutically acceptable salts, such as the citrate salt in which a quaternary ammonium (nosylate) salt of an appropriate piperidine is reacted with a corresponding 4-NOsulfonate ester to produce the desired piperidine derivative at a high purity.

Method of making piperidine derivatives

A method in which a crude chlorinated product of a phenylpropanolamine, preferably prepared by reacting thionyl chloride with the phenylpropanolamine, is purified by contacting an aqueous solution of the crude product with carbon. The carbon-treated solution of the crude chlorinated product of a phenylpropanolamine is catalytically hydrogenated to the corresponding amphetamine derivative.

Method of making amphetamine

A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R, R, R, R, R, R, Z and Z' are defined herein.

Process for preparation of probucol derivatives

Process for the preparation of probucol derivatives

Substituted alkylketo compounds and process

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Stereoselective reductive amination of ketones

Preparation of (S)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

A method is described for the preparation of water-soluble derivatives of probucol compounds having the following formula

Process for preparing probucol derivatives

Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.

Preparation of

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Charles City, IA, United States of America

Paul Alan Jass