Sandoz Gmbh

Paul A Stadler

Peter Stutz

Theodor Fehr

Gernot Wersin

Franz Troxler

Brian P Richardson

Gunter Engel

Gerald Breuleux, Legal Representative

Bruno Hugi

Peter Donatsch

The dicarboxylic, heterocyclic and substituted benzoic acid alkylene bridged piperidyl amides and esters are serotonin M antagonists.

Method of inducing a serotonin M receptor antagonist effect with

This invention provides compounds of ##STR1## wherein R.sub.1 is benzyl or benzyl substituted by hydroxy, chlorine, fluorine, amino, amido, (C.sub.2-5) alkanoylamino, (C.sub.1-4) alkyl, (C.sub.1-4) alkylamino, (C.sub.1-4) alkoxy, (C.sub.1-4) alkylamido, di[(C.sub.1-4) alkyl]amino, or di[(C.sub.1-4) alkyl]amino, R.sub.2, R.sub.4 and R.sub.5 are each (C.sub.1-4) alkyl, and R.sub.3 is (C.sub.2-4) alkyl are prolactin secretion promoters.

Ergot peptide alkaloid derivatives, processes for their preparation and

The invention provides indole compounds useful for the treatment of hypertension, processes for the preparation of said compounds and pharmaceutical compositions containing these compounds. The compounds of the invention have the formula ##STR1## wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R.sub.1 is H or alkyl, or A together with NR.sub.1 is 4-piperidyl, R.sub.2 is hydrogen or alkyl, R.sub.3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R.sub.4 is hydrogen, chlorine, bromine or alkyl, R.sub.5 is hydrogen, alkyl, alkoxy or alkylthio, and X is --CO-- or --CS.

N-Benzoyl-N'-3-indolyl-N'alkyl-1,3-diaminopropanes

This invention provides new compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,

8.alpha.-Substituted ergoline-I derivatives

The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine,

Sulfonamido and sulfamoylamino-ergoline-I derivatives

The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine and

N-9,10-Dihydrolysergyl-m-aminobenzoic acid amide derivative

This invention provides new compounds of formula I, ##STR1## wherein R is branched chain alkyl of 3 to 6 carbon atoms, useful as venoconstrictors and venotonics.

Ergopeptine derivatives

This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is alkyl or 2 to 5 carbon atoms, and

6-Branched chain alkyl sustituted ergot alkaloids

N-9,10-dihydrolysergyl-m-aminobenzoic acid amide derivative

This invention provides new compounds of formula I, ##STR1## wherein X Y IS THE GROUP ##STR2## and R is hydrogen, cyano, a 5- or 6-membered unsaturated heterocyclic radical attached through a ring carbon atom and having 1, 2 or 3 hetero ring atoms, the first hetero atom being nitrogen, oxygen or sulphur, and the second and third hetero atoms, if present, being nitrogen, or 2- or 4-pyridyl monosubstituted by lower alkyl, lower alkoxy or halogen, Useful as anti-Parkinson agents.

6-Methyl-8-thiomethyl-ergolene derivatives

The present invention provides compounds of the formula, ##STR1## wherein R.sub.1 is alkyl (C.sub.1-5),

8-Adamantylaminomethyl ergolene derivatives

The present invention provides a novel cyclization process useful for the production of the peptide moiety of an ergotalkaloid.

Process for preparing oxazolo�3,2-a!pyrrolo�2,1-c!pyrazine derivatives

Compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 4 carbon atoms,

Ergot peptide alkaloid derivatives

This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen, alkyl of 2 to 8 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms, and

6-Hydrocarbon-ergopeptines

This invention provides a new process for the preparation of a compound of formula I, ##STR1## wherein R' is alkyl or cycloalkyl, and

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Biel-Benken, Switzerland

Paul A Stadler