Gilead Sciences, Inc.

Constance Therapeutics, Inc.

Paul A Roethle

Ryan McFadden

Hong Yang

Randall Halcomb

Paul Hrvatin

Michael L Mitchell

Lianhong Xu

Kerim Babaoglu

Manoj C Desai

Hon Chung Hui

Hongtao Liu

Brandon Heath Brown

Yingmei Qi

Randall L Halcomb

John O Link

Gediminas J Brizgys

Hongyan Guo

Randall W Vivian

James G Taylor

Elizabeth M Bacon

Patricia Andres

Richard Y Huang

Fang Wang

Kyla Bjornson

Eric Lansdon

Constance Finley

Luke McKee

Haley Poole Bestwick

Ryan Mcfadden

Xiaowu Chen

Xiaochun Han

Richard Hung Chiu Yu

James D Trenkle

Krista Marie Diaz

Jessica Jade Chao

Erwina Rudio

Jake Cha

Yoo Joong Kim

Darin Allen

Luke Mckee

Richard Huang

Valeriya Smolenskaya

James Taylor

Ryan Mc Fadden

The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.

Solid forms of a toll-like receptor modulator

Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Modulators of toll-like receptors

The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.

Cannabis oil extracts and compositions

The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.

Therapeutic compounds

The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.

Methods of preparing toll-like receptor modulators

The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS

Naphthalene acetic acid derivatives against HIV infection

The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections

Growing community of inventors

San Francisco, CA, United States of America

Paul A Roethle