Genzyme Corporation

Paul A Konowicz

Clark Qun Pan

Luis Z Avila

Robert J Miller

James E Stefano

Yunxiang Zhu

Qun Zhou

Michael Reardon

Patrick Finn

Lauren Young

Joseph P Kutzko

Xiaoyang Zheng

John Harrahy

Duncan E Paterson

Andreas Peer

Adelya K Leshchiner

Min-Yeh Grace Chang

Valentina Vasilyeva

Michael R Reardon

Duncan Patterson

Duncan E Patterson

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Oligosaccharide-protein conjugates

Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.

Polymeric materials, their preparation and use

Growing community of inventors

Maynard, MA, United States of America

Paul A Konowicz