Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Paul A Khavari

M Peter Marinkovich

Alfred T Lane

Jean Tang

Zurab Siprashvili

Ngon T Nguyen

Hongran Fan

Katherine LaRoque Jameson

Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.

Gene therapy for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes

Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer.

Scaffold-kinase interaction blockades and uses thereof in treating cancer

Skin cells are genetically altered to express a gene product encoded by an introduced polynucleotide. Specifically, the invention involves introduction of a nucleotide of interest into a skin cell by topical application of a polynucleotide that is substantially free of liposomes or charged lipids, where the skin can be either treated or untreated prior to application. Similarly, the invention involves introduction of a nucleotide of interest into a skin cell by topical application of a polynucleotide formulation comprising a liposome or charged lipid, wherein the skin is not treated by removal of hair prior to application. The method of the invention serves as a platform for delivering polynucleotides to skin cells for expression therein for any of a variety uses including, but not limited to genetic immunization.

Introduction of nucleic acid into skin cells by topical application

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Palo Alto, CA, United States of America

Paul A Khavari