Merck + Co., Inc.

Schering Aktiengesellschaft

Trustees of the University of Penna.

Merch & Co., Inc.

Paul A Friedman

John J Baldwin

David C Remy

Andrew M Stern

David A Claremon

Philip J Provost

David L Krah

Joseph G Atkinson

George E Mark, Iii

Le T Duong

Bruce L Daugherty

Gabriel F Eilon

Richard A Dixon

Sanford J Shattil

Rebecca A Taub

John W Jacobs

Stephen J Gardell

Purified plasminogen activator proteins obtained or derived from the vampire bat Desmodus rotundus saliva and salivary glands, methods for purifying the proteins, DNA sequences encoding these proteins, means for producing them using recombinant DNA technology, pharmaceutical compositions comprising these proteins and methods of treatment utilizing these proteins are provided.

Vampire bat salivary plasminogen activators

Process for attenuated varicella zoster virus vaccine production

A live, attenuated varicella zoster virus vaccine is produced with enhanced yield of VZV. The new process makes mass production of a live VZV vaccine more practical.

Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either alone or together with plasminogen activator.

Methods for thrombolytic therapy

Peptides comprising the tripeptide sequence of arginine-tyrosine-aspartic acid, linked from amino- to carboxy-terminus, are inhibitors of fibrinogen binding, platelet aggregation, glycoprotein IIb-IIIa binding and related aberrant and normal physiological conditions.

Inhibitors of platelet binding

Various 3-substituted cyproheptadine derivatives are useful in the treatment of infection by Plasmodium falciparum and in the treatment of malaria either as compounds, pharmaceutically acceptable salts, or pharmaceutical composition ingredients in combination with antimalarial agents or compounds. Methods of treating malaria and methods of treating infection by Plasmodium falciparum are also described.

Method of traeting malaria with cyproheptadine derivatives

Methods and compositions for thrombolytic therapy

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Rosemont, PA, United States of America

Paul A Friedman